可见光诱导的自由基级联磺酰化/环化反应合成吲哚并吡啶衍生物

Du Qin, Pan Ruohan, Chen Yu, Tang Yucai

Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City) Changde 415000 China

College of Chemistry and Materials Engineering, Hunan University of Arts and Science, Engineering Technology Research Center of Key Preparation Technology of Biomedical Polymer Materials Changde 415000 China.

RSC Adv. 2025 Jan 2;15(1):216-222. doi: 10.1039/d4ra08000a.

Indole-fused pyridines are an important motif in pharmaceuticals and functional molecules. A visible-light induced Ru(bpy)Cl·6HO catalyzed radical cascade sulfonylation/cyclization strategy for the synthesis of indole-fused pyridine derivatives was developed. Diverse indole-fused pyridines bearing different functional groups were obtained in moderate to good yields. Compared with previous work, the easily accessible starting materials, molecular nitrogen as byproduct, and eco-friendly visible light as an energy source all make this transformation more sustainable and practical.

吲哚并吡啶是药物和功能分子中的重要结构单元。开发了一种可见光诱导的Ru(bpy)Cl·6H₂O催化的自由基串联磺酰化/环化策略，用于合成吲哚并吡啶衍生物。以中等至良好的产率获得了带有不同官能团的多种吲哚并吡啶。与先前的工作相比，起始原料易于获得、副产物为分子氮以及使用环保的可见光作为能源，所有这些都使这种转化更具可持续性和实用性。