Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
Department of Cardiac Surgery, The First Hospital of Jilin University, Changchun, Jilin Province, China.
Expert Rev Mol Diagn. 2022 Feb;22(2):213-222. doi: 10.1080/14737159.2021.1979960. Epub 2021 Dec 6.
Long non-coding RNAs (lncRNAs) play a critical role in genomic instability and prognosis of cancer patients, but the methods to identify genomic instability-related lncRNAs have yet to be established. In the present study, to assess the prognostic value of lncRNAs associated with genomic instability in clear cell renal cell carcinoma (ccRCC).A computational framework was established based on the mutation hypothesis and combined lncRNA expression and somatic mutation profiles of the ccRCC genome. Furthermore, a prognostic model was developed using the genome instability-derived lncRNA signature GILncSig based on three lncRNA genes (LINC02471, LINC01234, and LINC00460) and verified using multiple independent patient cohorts.This study established an effective computational method to study the role of lncRNAs in genomic instability, with potential applications in identifying new genomic instability-related cancer biomarkers.
长链非编码 RNA（lncRNA）在基因组不稳定性和癌症患者预后中发挥着关键作用，但鉴定与基因组不稳定性相关的 lncRNA 的方法尚未建立。本研究旨在评估与透明细胞肾细胞癌（ccRCC）中基因组不稳定性相关的 lncRNA 的预后价值。
本研究基于突变假说，结合 ccRCC 基因组的 lncRNA 表达和体细胞突变谱，建立了一个计算框架。此外，还基于三个 lncRNA 基因（LINC02471、LINC01234 和 LINC00460）的基因组不稳定性衍生 lncRNA 特征 GILncSig 开发了一个预后模型，并使用多个独立的患者队列进行了验证。
本研究建立了一种有效的计算方法来研究 lncRNA 在基因组不稳定性中的作用，具有识别新的与基因组不稳定性相关的癌症生物标志物的潜在应用。
