全面分析 TMC 家族成员在肾透明细胞癌中的预后和免疫浸润情况。
Comprehensive analysis of the prognosis and immune infiltration of TMC family members in renal clear cell carcinoma.
机构信息
Department of Urology, Changzheng Hospital, Naval Medical University, NO. 415 Fengyang Road, Shanghai, 200003, China.
Department of Urology, School of Medicine, Xiang'an Hospital of Xiamen University, Xiamen University, NO. 4221 Xiang'an South Road, Xiamen, 361101, Fujian Province, China.
出版信息
Sci Rep. 2023 Jul 19;13(1):11668. doi: 10.1038/s41598-023-38914-z.
Renal cancer is a common malignancy of the urinary system, and renal clear cell carcinoma (RCCC) is the most common pathological type. Transmembrane channel-like (TMC) protein is an evolutionarily conserved gene family containing 8 members, however there is still a lack of comprehensive analysis about TMC family members in RCCC. In this study, we analyzed the expression of TMC family members in RCCC from TCGA and investigated the prognosis values and immune infiltration of TMC family members in RCCC. We found that TMC2, TMC3, TMC5, TMC7 and TMC8 were significantly related with overall survival (OS) of RCCC patients. TMC3, TMC6, and TMC8 was positively correlated with the degree of immune infiltration in RCCC. TMC2, TMC6, TMC7, and TMC8 were positively correlated with immune checkpoint genes, whereas TMC4 was negative. According to KEGG and GO analysis, almost all TMCs except TMC4 were involved in the immune response. Thus, we may regard the TMC family members as novel biomarkers to predict potential prognosis and immunotherapeutic response in RCCC patients.
肾细胞癌是泌尿系统常见的恶性肿瘤，肾透明细胞癌（RCCC）是最常见的病理类型。跨膜通道样（TMC）蛋白是一个进化上保守的基因家族，包含 8 个成员，但关于 TMC 家族成员在 RCCC 中的综合分析仍然缺乏。在这项研究中，我们从 TCGA 分析了 RCCC 中 TMC 家族成员的表达，并研究了 TMC 家族成员在 RCCC 中的预后价值和免疫浸润。我们发现 TMC2、TMC3、TMC5、TMC7 和 TMC8 与 RCCC 患者的总生存率（OS）显著相关。TMC3、TMC6 和 TMC8 与 RCCC 中免疫浸润程度呈正相关。TMC2、TMC6、TMC7 和 TMC8 与免疫检查点基因呈正相关，而 TMC4 则相反。根据 KEGG 和 GO 分析，除了 TMC4 之外，几乎所有的 TMC 都参与了免疫反应。因此，我们可以将 TMC 家族成员视为预测 RCCC 患者潜在预后和免疫治疗反应的新型生物标志物。
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