中文按摩（推拿）联合石蜡疗法与单纯推拿或石蜡疗法治疗先天性肌性斜颈的系统评价及贝叶斯网状meta 分析方案
Chinese massage (Tuina) combline with paraffin therapy versus tuina or paraffin therapy alone for the treatment of congenital muscular torticollis: A protocol for systematic review and Bayesian network meta-analysis.
机构信息
Department of Orthopedics and Traumatology of Integrated Traditional Chinese and Western Medicine, Tianjin Hospital, Tianjin, China.
College of Acupuncture, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
出版信息
Medicine (Baltimore). 2021 Nov 5;100(44):e27648. doi: 10.1097/MD.0000000000027648.
BACKGROUND
Current studies in patients with congenital muscular torticollis (CMT) have predominantly focused on the role of tuina or paraffin therapy alone. This systematic review with Bayesian network meta-analysis will be performed to sum up the existing evidence on the effects and safety of tuina plus paraffin therapy for CMT in infants and children.
METHODS
The Preferred Reporting Items for Systematic Reviews and Meta-Analyzes reporting guidelines will be followed to conduct this study. The electronic databases of PubMed, Cochrane Library, PsycINFO, EMBASE, the Chinese Scientific Journal Database, China National Knowledge Infrastructure, WanFang Data, Taiwan Electronic Periodical Services, and Web of Science will be searched from the inception to November 2021 using the following key terms: "Tuina," "traditional Chinese medicine massage," "paraffin," and "congenital muscular torticollis," for all relevant studies. We impose no language restrictions. We include reports on randomized controlled trials (RCTs) and quasi-RCTs of Tuina combline with paraffin therapy for the treatment of CMT in children and adolescents. We include studies that assessed effective rate, symmetry, improvements of range of motion, muscle length, and sternocleidomastoid tumor thickness, quality of life, and adverse events. The Cochrane Bias Risk Tool, which considers sequence generation, allocation concealment, and blinding and other aspects of bias, will be used to assess the risk of bias in studies.
RESULTS
A Bayesian network meta-analysis is an appropriate statistical method to compare all treatment options by statistically simulating the estimated results of a comprehensive trial, and to compare treatments by common and associated comparators. In addition, Bayesian network meta-analysis can produce ranking probabilities of treatments, which may contribute to clinicians' clinical decision-making.
REGISTRATION NUMBER
10.17605/OSF.IO/K5EGN.
背景
目前针对先天性肌性斜颈（CMT）患者的研究主要集中在推拿或石蜡疗法单独应用的效果上。本系统评价采用贝叶斯网络荟萃分析方法，旨在汇总推拿联合石蜡疗法治疗婴幼儿 CMT 的现有疗效和安全性证据。
方法
本研究将遵循系统评价和荟萃分析的首选报告项目（PRISMA）报告指南进行。检索从建库至 2021 年 11 月，PubMed、Cochrane 图书馆、PsycINFO、EMBASE、中国科学引文数据库、中国知网、万方数据知识服务平台、台湾学术文献数据库、维普中文期刊服务平台和 Web of Science 等电子数据库，中文检索词包括“推拿”“中医按摩”“石蜡”和“先天性肌性斜颈”，英文检索词包括“Tuina”“traditional Chinese medicine massage”“paraffin”和“congenital muscular torticollis”，以查找所有相关研究。我们不对语言进行限制。纳入推拿联合石蜡疗法治疗儿童青少年 CMT 的随机对照试验（RCT）和准 RCT 报告。纳入研究的疗效评定指标包括有效率、两侧对称度、关节活动度、肌肉长度、胸锁乳突肌厚度的改善，生活质量和不良反应等。采用 Cochrane 偏倚风险工具评价纳入研究的偏倚风险，该工具从随机序列产生、分配隐藏和盲法等方面考虑偏倚风险。
结果
贝叶斯网络荟萃分析是一种适当的统计方法，可以通过统计模拟综合试验的估计结果，对所有治疗方案进行比较，并通过共同和相关比较对治疗方案进行比较。此外，贝叶斯网络荟萃分析可以产生治疗方案的排序概率，这可能有助于临床医生的临床决策。
注册号
10.17605/OSF.IO/K5EGN。
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