Department of Oncology, The People's Hospital of Dazu District, Chongqing, China.
Medicine (Baltimore). 2021 Nov 5;100(44):e27681. doi: 10.1097/MD.0000000000027681.
BACKGROUND: Cancer-related fatigue (CRF) is one of the most common adverse events of anticancer therapies, with an incidence of up to 90%, which seriously affects the quality of life in cancer patients. Complementary and alternative therapies for CRF include acupuncture, Chinese herbal medicine, Tai Chi, Qigong, and massage therapy. Several studies have shown that traditional Chinese medicine (TCM) exercise therapies, such as Tai Chi, Ba Duan Jin, the classics of tendon changing, Six Healing Sounds, and Wu Qin Xi, can improve CRF, anxiety symptoms, and sleep quality in cancer patients. However, their specific efficacy and which TCM exercise therapy is the best remain controversial. In this study, we assess and compare the effects of different TCM exercise therapies on CRF, anxiety, and sleep quality in cancer patients by network meta-analysis (NMA). METHODS: Randomized controlled trials reporting TCM exercise therapies for CRF, anxiety and sleep quality in cancer patients published before October 2021 will be searched in the PubMed, Web of Science, Scopus, Cochrane Library, Embase, China Scientific Journal Database, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and Wanfang Data. Two researchers will be independently responsible for literature screening, data extraction and assessment of their quality. Standard pair-wise and NMA will be performed to compare the efficacy of different TCM exercise therapies on CRF, anxiety and sleep quality in cancer patients using Stata 14.0 software. RESULTS: The results of this meta-analysis will be submitted to a peer-reviewed journal for publication. CONCLUSIONS: This NMA will contribute to identify the optimal TCM exercise therapy for CRF and provide evidence-based bias for clinical decision-making. ETHICS AND DISSEMINATION: Ethical approval was not required for this study. The systematic review will be published in a peer-reviewed journal, presented at conferences, and shared on social media platforms. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/MJ8DA.
背景：癌症相关性疲劳（CRF）是癌症治疗中最常见的不良反应之一，发生率高达 90%，严重影响癌症患者的生活质量。CRF 的补充和替代疗法包括针灸、中草药、太极拳、气功和按摩疗法。多项研究表明，太极拳、八段锦、易筋经、六字诀和五禽戏等中医运动疗法可以改善癌症患者的 CRF、焦虑症状和睡眠质量。然而，它们的具体疗效以及哪种中医运动疗法效果最好仍存在争议。在这项研究中，我们通过网络荟萃分析（NMA）评估和比较不同中医运动疗法对癌症患者 CRF、焦虑和睡眠质量的影响。
方法：我们将检索 2021 年 10 月前发表的关于中医运动疗法治疗癌症患者 CRF、焦虑和睡眠质量的随机对照试验，检索数据库包括 PubMed、Web of Science、Scopus、Cochrane Library、Embase、中国科学引文数据库、中国国家知识基础设施、中国生物医学文献数据库和万方数据。两位研究人员将独立负责文献筛选、数据提取和质量评估。使用 Stata 14.0 软件，通过标准的成对和 NMA 比较不同中医运动疗法对癌症患者 CRF、焦虑和睡眠质量的疗效。
结果：该荟萃分析的结果将提交给同行评议期刊发表。
结论：这项 NMA 将有助于确定治疗 CRF 的最佳中医运动疗法，并为临床决策提供基于证据的偏见。
伦理与传播：本研究无需伦理批准。系统评价将发表在同行评议期刊上，在会议上展示，并在社交媒体平台上分享。
OSF 注册号：DOI 10.17605/OSF.IO/MJ8DA。
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