Yu Haiyang, Wang Haiyan, Ma Tao, Huang Ailing, Lu Zengpeng, Zhang Xiaogang
Clinical College of Chinese Medicine, Gansu University of Chinese Medicine.
Department of Orthopedics.
Medicine (Baltimore). 2020 Oct 2;99(40):e22547. doi: 10.1097/MD.0000000000022547.
chronic low back pain (CLBP) are common symptoms bothering people in daily life. Traditional Chinese medicine (TCM) nonpharmacological interventions are gaining an increasing popularity for CLBP. Nevertheless, the evidence of efficacy and safety of random controlled trials (RCTs) remains controversial. This study aims to evaluate the efficacy and acceptability of different TCM nonpharmacological therapies by systematic review and network meta-analysis.
According to the strategy, The authors will retrieve a total of 7 electronic databases by September 2020, including PubMed, the Cochrane Library, EMbase, China National Knowledge Infrastructure, China Biological Medicine, Chongqing VIP, and Wan-fang databases After a series of screening, 2 researchers will use Aggregate Data Drug Information System and Stata software to analyze the data extracted from the randomized controlled trials of TCM nonpharmacological interventions for CLBP. The primary outcome will be the improvement of Pain intensity and functional status/disability and the secondary outcomes will include lobal improvement, health-related quality of life, satisfaction with treatment, and adverse events. Both classical meta-analysis and network meta-analysis will be implemented to investigate direct and indirect evidences on this topic. The quality of the evidence will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation instrument.
This study will provide a reliable evidence for the selection of TCM nonpharmacological therapies in the treatment of CLBP.
This study will generate evidence for different TCM nonpharmacological therapies for CLBP and provide a decision-making reference for clinical research.
This study does not require ethical approval. The results will be disseminated through a peer-reviewed publication.
DOI 10.17605/OSF.IO/4H3Y9.
慢性下腰痛（CLBP）是困扰人们日常生活的常见症状。中医非药物干预在CLBP治疗中越来越受欢迎。然而，随机对照试验（RCT）的疗效和安全性证据仍存在争议。本研究旨在通过系统评价和网络荟萃分析评估不同中医非药物疗法的疗效和可接受性。
根据该策略，作者将于2020年9月前共检索7个电子数据库，包括PubMed、Cochrane图书馆、EMbase、中国知网、中国生物医学数据库、重庆维普数据库和万方数据库。经过一系列筛选后，两名研究人员将使用汇总数据药物信息系统和Stata软件分析从CLBP中医非药物干预随机对照试验中提取的数据。主要结局将是疼痛强度和功能状态/残疾的改善，次要结局将包括整体改善、健康相关生活质量、治疗满意度和不良事件。将同时进行经典荟萃分析和网络荟萃分析，以研究该主题的直接和间接证据。将使用推荐评估、制定和评价工具对证据质量进行评估。
本研究将为CLBP治疗中中医非药物疗法的选择提供可靠证据。
本研究将为CLBP的不同中医非药物疗法提供证据，并为临床研究提供决策参考。
本研究无需伦理批准。研究结果将通过同行评审出版物进行传播。
OSF注册号：DOI 10.17605/OSF.IO/4H3Y9。
