Champault G, Michel F, Callard P, Garnier M, Legoult J, Soulier Y, Burnichon J, Mannoux A, Patel J C
J Chir (Paris). 1978 Apr;115(4):233-42.
The author's studied pancreatic autotransplants and allotransplants in the gastric submucosa of the rabbit after removal of the pancreas. Pancreatctomy causes severe diabetes with hyperkaliemic acidosis which is always fatal with 72 hours. Auto or allotransplantation cures the diabetes within two to three days, and maintains normal glucose balance for about 60 days. Early death after transplantation occurred when the graft was totally ineffective. After transplantation, the blood sugar rose progressively towards the 15th day, then suddenly and definetely at the time of necrosis of the graft towards the 15th or 21st day. The follow up in some transplanted animals exceeded two months. The interest of the procedure resides in the implantation of a large critical mass (25 to 30% of the pancreas ) in a well-vascularised area, drained by the portal system, and permitting the digestive tract elimination of the pancreatic necrosis whether of vascular or immune origin.
作者研究了切除胰腺后在兔胃黏膜下层进行胰腺自体移植和异体移植的情况。胰腺切除会导致严重的糖尿病并伴有高钾性酸中毒，72小时内通常会致命。自体或异体移植可在两到三天内治愈糖尿病，并维持约60天的正常血糖平衡。当移植物完全无效时，移植后会早期死亡。移植后，血糖在第15天逐渐升高，然后在移植物坏死时，即第15天或第21天突然且肯定地升高。一些移植动物的随访时间超过了两个月。该手术的意义在于将大量关键组织（占胰腺的25%至30%）植入血管丰富的区域，由门静脉系统引流，并允许消化道清除无论是血管性还是免疫性起源的胰腺坏死组织。
