Faculty of Exact and Natural Sciences, Grupo de Investigación Avanzada en Biomedicina, Universidad Libre Barranquilla, Barranquilla, Colombia.
Faculty of Health Sciences, Universidad Libre Seccional Barranquilla, Barranquilla, Colombia.
Curr Pediatr Rev. 2022;18(2):121-137. doi: 10.2174/1573396317666211206124347.
Pediatric coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) have been recognized in multiple countries globally. In this review, we provide recent insights into SARS-CoV-2 infection in children from epidemiological, clinical, and laboratory perspectives, including reports on the disease course and therapy. We highlight key features of SARS-CoV-2 infection in children, the relationship between MIS-C and Kawasaki disease, and summarize treatment guidelines for COVID-19 in children from institutional protocols from Colombia, case reports, recommendations based on expert consensus, and official statements from organizations such as the World Health Organization (WHO), United States Center for Disease Control (CDC), Colombian Association of Infectious Diseases, and the Colombian Society of Pediatrics. Finally, we discuss gaps in research with suggestions for future research on the pathogenesis underlying pediatric COVID-19.
全球多个国家已经认识到儿童 2019 年冠状病毒病（COVID-19）和儿童多系统炎症综合征（MIS-C）。在这篇综述中，我们从流行病学、临床和实验室的角度提供了关于儿童 SARS-CoV-2 感染的最新见解，包括关于疾病过程和治疗的报告。我们强调了儿童 SARS-CoV-2 感染的关键特征、MIS-C 与川崎病的关系，并总结了来自哥伦比亚机构方案、病例报告、基于专家共识的建议以及世界卫生组织（WHO）、美国疾病控制与预防中心（CDC）、哥伦比亚传染病协会和哥伦比亚儿科学会等组织的官方声明的儿童 COVID-19 治疗指南。最后，我们讨论了研究中的差距，并就儿童 COVID-19 发病机制的未来研究提出了建议。
