Division of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Division of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, USA; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Rheum Dis Clin North Am. 2023 Aug;49(3):647-659. doi: 10.1016/j.rdc.2023.03.002. Epub 2023 Mar 17.
Multisystem inflammatory syndrome in children (MIS-C) is a delayed postinflammatory disorder associated with the previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially, MIS-C was described as highly similar to Kawasaki disease (KD), a pediatric febrile systemic vasculitis that can lead to the development of coronary artery aneurysms (CAAs). While KD and MIS-C are both inflammatory disorders, the 2 entities differ in their epidemiological, clinical, immunological, and pathological features. MIS-C clinical and laboratory characteristics are more closely related to toxic shock syndrome (TSS) than KD, which informs the understanding of pathogenesis and potential therapeutic approaches.
儿童多系统炎症综合征（MIS-C）是一种与严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）先前感染相关的迟发性炎症后疾病。最初，MIS-C 被描述为与川崎病（KD）高度相似，KD 是一种儿科发热性全身血管炎，可导致冠状动脉瘤（CAA）的发展。虽然 KD 和 MIS-C 都是炎症性疾病，但这两种疾病在流行病学、临床、免疫学和病理学特征上有所不同。MIS-C 的临床和实验室特征与中毒性休克综合征（TSS）更为密切相关，而非 KD，这有助于理解其发病机制和潜在的治疗方法。
