Agossou M, Venissac N
Service de pneumologie, CHU de Martinique, route de Chateauboeuf, 97261 Fort-de-France, Martinique.
Service de chirurgie thoracique, CHRU de Lille, Lille, France.
Rev Mal Respir. 2022 Feb;39(2):175-178. doi: 10.1016/j.rmr.2021.11.002. Epub 2021 Dec 3.
Pleural fluid effusion is a possible harmful effect of sodium valproate. It most often consists in polynuclear eosinophilic pleurisy and occurs within months of treatment initiation.
We report on a case of sodium valproate-induced pleural effusion occurring more than 12years after initiation of treatment. The original formula was variegated and not eosinophilic. The patient exhibited contralateral recurrence with continued treatment. Once treatment was discontinued, there was no recurrence during three-year follow-up.
Sodium valproate-induced pleural effusion can present an atypical polymorphous picture leading to erroneous diagnoses.
胸腔积液是丙戊酸钠可能产生的有害影响。它最常见的表现为多核嗜酸性胸膜炎，且在治疗开始后的数月内出现。
我们报告一例在治疗开始12年多后发生的丙戊酸钠所致胸腔积液病例。原始积液成分多样，并非嗜酸性。患者在持续治疗过程中出现对侧复发。一旦停药，在三年随访期间未再复发。
丙戊酸钠所致胸腔积液可能呈现非典型的多形性表现，从而导致误诊。
