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全民补贴连续血糖监测在 1 型糖尿病青少年中的应用:基于人群的 2 年研究结果显示的使用率和结局。

Universal Subsidized Continuous Glucose Monitoring Funding for Young People With Type 1 Diabetes: Uptake and Outcomes Over 2 Years, a Population-Based Study.

机构信息

Department of Endocrinology and Diabetes, Queensland Children's Hospital, Brisbane, Queensland, Australia.

Faculty of Medicine, University of Queensland, Herston, Queensland, Australia.

出版信息

Diabetes Care. 2022 Feb 1;45(2):391-397. doi: 10.2337/dc21-1666.

Abstract

OBJECTIVE

Continuous glucose monitoring (CGM) is increasingly used in type 1 diabetes management; however, funding models vary. This study determined the uptake rate and glycemic outcomes following a change in national health policy to introduce universal subsidized CGM funding for people with type 1 diabetes aged <21 years.

RESEARCH DESIGN AND METHODS

Longitudinal data from 12 months before the subsidy until 24 months after were analyzed. Measures and outcomes included age, diabetes duration, HbA1c, episodes of diabetic ketoacidosis and severe hypoglycemia, insulin regimen, CGM uptake, and percentage CGM use. Two data sources were used: the Australasian Diabetes Database Network (ADDN) registry (a prospective diabetes database) and the National Diabetes Service Scheme (NDSS) registry that includes almost all individuals with type 1 diabetes nationally.

RESULTS

CGM uptake increased from 5% presubsidy to 79% after 2 years. After CGM introduction, the odds ratio (OR) of achieving the HbA1c target of <7.0% improved at 12 months (OR 2.5, P < 0.001) and was maintained at 24 months (OR 2.3, P < 0.001). The OR for suboptimal glycemic control (HbA1c ≥9.0%) decreased to 0.34 (P < 0.001) at 24 months. Of CGM users, 65% used CGM >75% of time, and had a lower HbA1c at 24 months compared with those with usage <25% (7.8 ± 1.3% vs. 8.6 ± 1.8%, respectively, P < 0.001). Diabetic ketoacidosis was also reduced in this group (incidence rate ratio 0.49, 95% CI 0.33-0.74, P < 0.001).

CONCLUSIONS

Following the national subsidy, CGM use was high and associated with sustained improvement in glycemic control. This information will inform economic analyses and future policy and serve as a model of evaluation diabetes technologies.

摘要

目的

连续血糖监测(CGM)在 1 型糖尿病管理中的应用日益增多;然而,资金模式各不相同。本研究旨在确定在国家卫生政策改变以引入全民补贴 CGM 资金用于 21 岁以下 1 型糖尿病患者后的采用率和血糖结果。

研究设计和方法

分析了补贴前 12 个月至补贴后 24 个月的纵向数据。措施和结果包括年龄、糖尿病病程、HbA1c、糖尿病酮症酸中毒和严重低血糖发作、胰岛素方案、CGM 采用率以及 CGM 使用百分比。使用了两个数据源:澳大拉西亚糖尿病数据库网络(ADDN)登记处(一个前瞻性糖尿病数据库)和国家糖尿病服务计划(NDSS)登记处,该登记处包括全国几乎所有的 1 型糖尿病患者。

结果

CGM 采用率从补贴前的 5%增加到 2 年后的 79%。CGM 引入后,12 个月时达到 HbA1c<7.0%目标的优势比(OR)提高(OR 2.5,P<0.001),24 个月时保持(OR 2.3,P<0.001)。24 个月时,血糖控制不佳(HbA1c≥9.0%)的 OR 降至 0.34(P<0.001)。CGM 用户中,65%的人使用 CGM 的时间超过 75%,24 个月时的 HbA1c 低于使用时间<25%的患者(分别为 7.8±1.3%和 8.6±1.8%,P<0.001)。该组中糖尿病酮症酸中毒也减少(发生率比 0.49,95%CI 0.33-0.74,P<0.001)。

结论

在国家补贴后,CGM 的使用率很高,并与持续改善血糖控制相关。这些信息将为经济分析和未来的政策提供信息,并作为评估糖尿病技术的模型。

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