Addala Ananta, Amedari Mcking I, Figg Lauren E, Ebekozien Osagie
Division of Pediatric Endocrinology, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
Diabetologia. 2025 Jul 22. doi: 10.1007/s00125-025-06494-4.
This narrative review applies neo-materialist theory to examine disparities in diabetes care across four domains: clinical trials, diabetes technology, immunotherapies and adjuvant digital technologies. Although systemic marginalisation can occur in many forms (e.g. based on ability, language, sex, gender or age), this review focuses on marginalisation based on race, ethnicity and socioeconomic status, as these are the key areas supported by the current evidence base. Under-representation of minoritised groups in clinical trials of diabetes interventions may limit the generalisability of the data generated. Contributing factors to under-representation include historical mistrust, exclusionary criteria and lack of cultural competence in research. Potential solutions to these disparities include revising trial protocols, engaging community partners and improving recruitment strategies; however, studies examining these solutions are limited. Disparities in access to diabetes technologies, such as continuous glucose monitoring and artificial pancreas systems, appear to be influenced by intersectional factors including race, ethnicity, socioeconomic status and insurance coverage. Despite awareness of these disparities, gaps in technology use persist because the causal pathways that determine these disparities are complex. Solutions are likely to involve education, improved access and policy reforms to address social and structural determinants of health. Disparities in access to immunotherapies, particularly in type 1 diabetes, may stem in part from under-representation of minoritised groups in research. Strategies to address these disparities include ensuring equitable access and performing inclusive data collection on social determinants of health. The digital divide in diabetes care is a key barrier to adjuvant digital technology use, with unequal access to smartphones, broadband and telemedicine. Bridging this gap will require improved infrastructure, increased access to digital tools and targeted telemedicine interventions to enhance care in underserved populations. Addressing these disparities requires comprehensive multifaceted strategies that recognise the complexity of structural inequities, including policy changes, improved technology access and inclusive research practices.
这篇叙述性综述运用新唯物主义理论,审视了糖尿病护理在四个领域的差异:临床试验、糖尿病技术、免疫疗法和辅助数字技术。尽管系统性边缘化可能以多种形式出现(例如基于能力、语言、性别或年龄),但本综述聚焦于基于种族、民族和社会经济地位的边缘化,因为这些是当前证据基础所支持的关键领域。在糖尿病干预措施的临床试验中,少数群体代表性不足可能会限制所产生数据的普遍性。导致代表性不足的因素包括历史上的不信任、排他性标准以及研究中缺乏文化能力。解决这些差异的潜在方案包括修订试验方案、让社区伙伴参与以及改进招募策略;然而,检验这些解决方案的研究有限。获取糖尿病技术(如持续葡萄糖监测和人工胰腺系统)方面的差异似乎受到多种交叉因素的影响,包括种族、民族、社会经济地位和保险覆盖范围。尽管人们意识到了这些差异,但技术使用方面的差距仍然存在,因为决定这些差异的因果路径很复杂。解决方案可能涉及教育、改善获取途径以及政策改革,以解决健康的社会和结构决定因素。在获取免疫疗法方面的差异,尤其是在1型糖尿病中,可能部分源于少数群体在研究中的代表性不足。解决这些差异的策略包括确保公平获取,并就健康的社会决定因素进行包容性的数据收集。糖尿病护理中的数字鸿沟是辅助数字技术使用的关键障碍,在智能手机、宽带和远程医疗的获取方面存在不平等。弥合这一差距将需要改善基础设施、增加数字工具的获取机会以及有针对性的远程医疗干预措施,以加强服务不足人群的护理。解决这些差异需要全面的多方面策略,认识到结构性不平等的复杂性,包括政策变化、改善技术获取途径和包容性研究实践。