Department of Child Healthcare and Scientific Education Section, Affiliated Matern & Child Care Hospital of Nantong University, Nantong.
Finance Section, Affiliated Traditional Chinese Medicine Hospital of Nantong University, Nantong.
Blood Press Monit. 2022 Apr 1;27(2):121-127. doi: 10.1097/MBP.0000000000000576.
Studies on the association of apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB) with hypertension (HTN) prevalence in patients with coronary artery disease (CAD) are limited. This cross-sectional study aimed to investigate this association in Chinese people in Wuhan, China.
Serum ApoA1 and ApoB levels were measured by immunoturbidimetry assay. Logistic regression analysis was used to estimate the associations of ApoA1 and ApoB level and ApoB/A1 ratio with HTN prevalence.
We included 5192 individuals (3060 men, mean age 61 years; 4412 HTN cases) in this study. After adjusting for covariates, serum ApoA1 but not ApoB level or ApoB/A1 ratio was inversely associated with HTN prevalence. HTN prevalence was reduced with the fifth versus first quintile of ApoA1 level [odds ratio = 0.78 (95% confidence interval 0.62-0.98)]. In stratified analyses based on sex, the probability of HTN with the fifth versus first ApoA1 level was 0.71 (0.53-0.96) for men. The probability of HTN with the fifth versus first quintile of ApoB/A1 ratio was 1.54 (1.11-2.13) after adjustment. With quintiles 2-5 versus of ApoB level, the probability of HTN did not differ in both men and women. On path analyses, the association of ApoA1 level and ApoB/A1 ratio with HTN was mediated by BMI (β coefficients: -0.179 to 0.133).
In general, high serum ApoA1 level may be associated with a reduced probability of HTN prevalence in patients with CAD in China, and this association may be mediated by BMI.
关于载脂蛋白 A1（ApoA1）和载脂蛋白 B（ApoB）与冠心病（CAD）患者高血压（HTN）患病率之间的关联的研究有限。本横断面研究旨在调查中国武汉人群中的这种关联。
通过免疫比浊法测定血清 ApoA1 和 ApoB 水平。使用 logistic 回归分析来估计 ApoA1 和 ApoB 水平以及 ApoB/A1 比值与 HTN 患病率的关联。
本研究共纳入 5192 名个体（3060 名男性，平均年龄 61 岁；4412 例 HTN 病例）。在调整了混杂因素后，血清 ApoA1 水平而不是 ApoB 水平或 ApoB/A1 比值与 HTN 患病率呈负相关。与 ApoA1 水平的第五个五分位相比，HTN 患病率降低[比值比=0.78（95%置信区间 0.62-0.98)]。基于性别进行分层分析，与 ApoA1 水平的第五个五分位相比，男性发生 HTN 的可能性为 0.71（0.53-0.96）。调整后，与 ApoB/A1 比值的第五个五分位相比，发生 HTN 的可能性为 1.54（1.11-2.13）。与 ApoB 水平的五分位 2-5 相比，男性和女性发生 HTN 的可能性并无差异。在路径分析中，ApoA1 水平和 ApoB/A1 比值与 HTN 的关联由 BMI 介导（β系数：-0.179 至 0.133）。
一般来说，高血清 ApoA1 水平可能与中国 CAD 患者 HTN 患病率降低相关，这种关联可能由 BMI 介导。
