Dong Hongli, Ni Wenqing, Bai Yamin, Yuan Xueli, Zhang Yan, Zhang Hongmin, Sun Yuanying, Xu Jian
Scientific Education Section and Department of Child Healthcare, Affiliated Maternity & Child Health Care Hospital of Nantong University, Nantong, China.
Department of Elderly Health Management, Shenzhen Center for Chronic Disease Control, Shenzhen, China.
Sci Rep. 2022 Feb 17;12(1):2751. doi: 10.1038/s41598-022-06829-w.
Apolipoproteins exert a key role on glucose metabolism; however, scarce data have examined the relationship between apolipoproteins and glycated haemoglobin (HbA1c) in Chinese adults. This study determined the cross-sectional and longitudinal associations of serum Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB) and the ApoB/A1 ratio with HbA1c in Chinese adults. A total of 1448 subjects (584 men and 864 women) aged 54.8 years were included in a baseline survey, and the concentrations of Apo and HbA1c were measured. A total of 826 participants were followed up approximately once after 3.94 ± 0.62 years. In cross-sectional analysis, serum ApoA1 was inversely associated with HbA1c, while ApoB and the ApoB/A1 ratio were positively associated with HbA1c. After further adjusting for the potential covariates, a higher ApoA1 was associated with lower HbA1c (Quartile 4 [Q4] vs. Q1 = 5.673% vs. 5.796%, P-trend = 0.014). In contrast, positive association of ApoB concentration and the ApoB/A1 ratio with HbA1c level were showed (Q4 vs. Q1 = 5.805% vs. 5.589% for ApoB; Q4 vs. Q1 = 5.841% vs. 5.582% for ApoB/A1 ratio). The longitudinal results showed no significant associations of ApoA1, ApoB levels and the ApoB/A1 ratio with HbA1c changes (all P-trends > 0.05). Path analysis suggested that body mass index did not have mediating effect on Apo-HbA1c association. Our findings revealed that higher ApoA1, lower ApoB concentrations and the ApoB/A1 ratio were associated with lower HbA1c level in Chinese adults.
载脂蛋白在葡萄糖代谢中发挥关键作用；然而，在中国成年人中，关于载脂蛋白与糖化血红蛋白（HbA1c）之间关系的研究数据较少。本研究确定了中国成年人血清载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB）以及ApoB/A1比值与HbA1c的横断面和纵向关联。共有1448名年龄为54.8岁的受试者（584名男性和864名女性）纳入基线调查，并测量了载脂蛋白和HbA1c的浓度。约3.94±0.62年后，共有826名参与者接受了一次随访。在横断面分析中，血清ApoA1与HbA1c呈负相关，而ApoB和ApoB/A1比值与HbA1c呈正相关。在进一步调整潜在协变量后，较高的ApoA1与较低的HbA1c相关（四分位数4[Q4]与Q1 = 5.673%与5.796%，P趋势 = 0.014）。相比之下，则显示ApoB浓度和ApoB/A1比值与HbA1c水平呈正相关（ApoB的Q4与Q1 = 5.805%与5.589%；ApoB/A1比值的Q4与Q1 = 5.841%与5.582%）。纵向结果显示，ApoA1、ApoB水平和ApoB/A1比值与HbA1c变化无显著关联（所有P趋势>0.05）。路径分析表明，体重指数对载脂蛋白-HbA1c关联无中介作用。我们的研究结果表明，在中国成年人中，较高的ApoA1、较低的ApoB浓度和ApoB/A1比值与较低的HbA1c水平相关。
