迟发性皮肤卟啉症光毒性反应中的补体裂解产物

Complement cleavage products in the phototoxic reaction of porphyria cutanea tarda.

作者信息

Pigatto P D, Polenghi M M, Altomare G F, Giacchetti A, Cirillo R, Finzi A F

出版信息

Br J Dermatol. 1986 May;114(5):567-73. doi: 10.1111/j.1365-2133.1986.tb04063.x.

DOI:10.1111/j.1365-2133.1986.tb04063.x

Abstract

We have measured C3, C4, CH50 and complement cleavage products C3a and C5a in in sera and plasma from PCT patients and normal controls 10 min and 1, 4 and 24 h after UVA irradiation. We found elevated C3a concentrations in PCT patients immediately after UVA irradiation and 24 h later. The same was true for CH50, whereas C3, C4 and C5a did not change significantly. No such changes occurred in normal controls. Our data suggest that activation of the complement cleavage product C3a by porphyrin and UV light triggers a series of events that cause tissue damage.

摘要

我们在卟啉病（PCT）患者及正常对照者接受紫外线A（UVA）照射后10分钟、1小时、4小时及24小时的血清和血浆中，检测了补体C3、C4、总补体活性（CH50）以及补体裂解产物C3a和C5a。我们发现，PCT患者在UVA照射后即刻及24小时后，C3a浓度升高。CH50的情况亦是如此，而C3、C4和C5a无显著变化。正常对照者未出现此类变化。我们的数据表明，卟啉和紫外线对补体裂解产物C3a的激活引发了一系列导致组织损伤的事件。