从发育到癌症——AGR2的作用不断增强。
From development to cancer - an ever-increasing role of AGR2.
作者信息
Jach Daria, Cheng Yuzhu, Prica Filip, Dumartin Laurent, Crnogorac-Jurcevic Tatjana
机构信息
Centre for Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London London, UK.
Institute of Human Genetics, International Centre for Life, Newcastle University Newcastle Upon Tyne, UK.
出版信息
Am J Cancer Res. 2021 Nov 15;11(11):5249-5262. eCollection 2021.
Abstract
Anterior gradient 2, AGR2, is a small, 20 kDa protein that plays a vital role in oxidative protein folding in the endoplasmic reticulum. AGR2 is involved in several signal transduction pathways that are essential for cell survival. It was initially discovered in the African clawed frog, , where it plays an important function in embryonic development. Akin to several other developmental genes, it is also frequently deregulated in cancer, where it plays a decisive role in tumor initiation, progression and metastasis. In this review, we have summarized currently known AGR2 functions, its expression and function in embryonic and cancer development, as well as its potential as a candidate tumor biomarker and promising new target for cancer immunotherapy.
摘要
前梯度2（AGR2）是一种分子量为20 kDa的小蛋白，在内质网的氧化蛋白折叠过程中发挥着至关重要的作用。AGR2参与了多个对细胞存活至关重要的信号转导通路。它最初是在非洲爪蟾中发现的，在胚胎发育中发挥重要功能。与其他几个发育基因类似，它在癌症中也经常失调，在肿瘤的起始、进展和转移中起决定性作用。在这篇综述中，我们总结了目前已知的AGR2的功能、其在胚胎发育和癌症发展中的表达及功能，以及它作为候选肿瘤生物标志物的潜力和癌症免疫治疗的新的有前景的靶点。
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