Department of Electro-Optical Engineering, National Taipei University of Technology, Taipei, 10608, Taiwan.
Department of Materials and Mineral Resources Engineering, Institute of Mineral Resources Engineering, National Taipei University of Technology, Taipei, 10608, Taiwan.
Mikrochim Acta. 2021 Dec 6;189(1):16. doi: 10.1007/s00604-021-05118-z.
As a novel two-dimensional (2D) material, metal carbide (MXene) has been identified as a hotspot research topic in the field of surface-enhanced Raman spectroscopy (SERS). Herein, we report the increment of SERS activity of titanium carbide (TiC) by incorporation of gold nanoparticles (Au NPs) by a facile photoreduction process for the detection of antipsychotic drug. TiC anchored with Au NPs produce a remarkable SERS enhancement by the synergistic action of chemical and electromagnetic mechanisms. The hotspots are formed in the nanometer-scale gaps between Au NPs on the TiC surface for the effective interaction with probe molecules. The proposed TiC/Au-NPs SERS substrate was employed for the detection of chlorpromazine (CPZ) with the wide linear range of 10-10 M and the ultra-low limit of detection of 3.92 × 10 M. Besides, the SERS effect of the optimized TiC/Au-NPs for the 532 nm excitation exhibits the enhancement factor in the order of 10 with the relative standard deviation of < 13% for the uniformity and < 8.80% for the reproducibility. To ensure the practical feasibility of the proposed TiC/Au-NPs SERS substrate, the spike and recovery method was used for the detection of CPZ in human biological fluids like urine and saliva. This work can open up a new approach to improve the SERS activity of MXene-based SERS substrate for practical applications, especially the determination of antipsychotic drugs in environmental pollution management.
作为一种新型二维（2D）材料，金属碳化物（MXene）已被确定为表面增强拉曼光谱（SERS）领域的热门研究课题。在此，我们通过简便的光还原过程报道了金纳米粒子（Au NPs）掺入碳化钛（TiC）后 SERS 活性的增强，用于检测抗精神病药物。TiC 通过与 Au NPs 的协同作用，在 TiC 表面的纳米级 Au NPs 之间形成了显著的 SERS 增强效应，从而实现与探针分子的有效相互作用。所提出的 TiC/Au-NPs SERS 基底用于检测氯丙嗪（CPZ），线性范围为 10-10 M，检测限低至 3.92×10 M。此外，优化后的 TiC/Au-NPs 在 532nm 激发下的 SERS 效应的增强因子为 10 数量级，其均匀性的相对标准偏差<13%，重现性的相对标准偏差<8.80%。为了确保所提出的 TiC/Au-NPs SERS 基底的实际可行性，采用加标回收法检测了尿液和唾液等人体生物液体中的 CPZ。这项工作为提高基于 MXene 的 SERS 基底的 SERS 活性开辟了一条新途径，特别适用于环境污染管理中抗精神病药物的测定。
