Department of Information Technology (INTEC-WAVES/IMEC), Ghent University/IMEC, Technologiepark 126Zwijnaarde, 9052, Belgium.
J Neural Eng. 2021 Dec 28;18(6). doi: 10.1088/1741-2552/ac3f6d.
. To investigate computationally the interaction of combined electrical and ultrasonic modulation of isolated neurons and of the parkinsonian cortex-basal ganglia-thalamus loop.. Continuous-wave or pulsed electrical and ultrasonic neuromodulation is applied to isolated Otsuka plateau-potential generating subthalamic nucleus (STN) and Pospischil regular, fast and low-threshold spiking cortical cells in a temporally alternating or simultaneous manner. Similar combinations of electrical/ultrasonic waveforms are applied to a parkinsonian biophysical cortex-basal ganglia-thalamus neuronal network. Ultrasound-neuron interaction is modelled respectively for isolated neurons and the neuronal network with the NICE and SONIC implementations of the bilayer sonophore underlying mechanism. Reduction inα-βspectral energy is used as a proxy to express improvement in Parkinson's disease by insonication and electrostimulation.. Simultaneous electro-acoustic stimulation achieves a given level of neuronal activity at lower intensities compared to the separate stimulation modalities. Conversely, temporally alternating stimulation with50 Hzelectrical and ultrasound pulses is capable of eliciting100 HzSTN firing rates. Furthermore, combination of ultrasound with hyperpolarizing currents can alter cortical cell relative spiking regimes. In the parkinsonian neuronal network, continuous-wave and pulsed ultrasound reduce pathological oscillations by different mechanisms. High-frequency pulsed separated electrical and ultrasonic deep brain stimulation (DBS) reduce pathologicalα-βpower by entraining STN-neurons. In contrast, continuous-wave ultrasound reduces pathological oscillations by silencing the STN. Compared to the separated stimulation modalities, temporally simultaneous or alternating electro-acoustic stimulation can achieve higher reductions inα-βpower for the same safety contraints on electrical/ultrasonic intensity.. Focused ultrasound has the potential of becoming a non-invasive alternative of conventional DBS for the treatment of Parkinson's disease. Here, we elaborate on proposed benefits of combined electro-acoustic stimulation in terms of improved dynamic range, efficiency, spatial resolution, and neuronal selectivity.
. 为了从计算角度研究孤立神经元和帕金森病皮层-基底节-丘脑环路的联合电和超声调制的相互作用。. 连续波或脉冲电和超声神经调节以时间交替或同时的方式施加于分离的大冢高原电位产生的丘脑底核 (STN) 和 Pospischil 规则、快速和低阈值放电皮质细胞。类似的电/超声波形组合施加于帕金森病生物物理皮层-基底节-丘脑神经元网络。超声-神经元相互作用分别使用双层声子底层机制的 NICE 和 SONIC 实现来模拟孤立神经元和神经元网络。使用α-β 光谱能量减少作为通过超声和电刺激改善帕金森病的替代物。. 与单独刺激模式相比，同时电声刺激以较低的强度达到给定的神经元活动水平。相反，50Hz 电和超声脉冲的时间交替刺激能够引发 100Hz STN 放电率。此外，超声与超极化电流的组合可以改变皮质细胞的相对放电模式。在帕金森病神经元网络中，连续波和脉冲超声通过不同的机制减少病理性振荡。高频脉冲分离的电和超声深部脑刺激 (DBS) 通过使 STN 神经元同步来减少病理性α-β 功率。相比之下，连续波超声通过沉默 STN 来减少病理性振荡。与单独的刺激模式相比，同时或交替的电声刺激可以在相同的电/超声强度安全限制下，实现更高的α-β 功率降低。. 聚焦超声有可能成为治疗帕金森病的传统 DBS 的非侵入性替代方法。在这里，我们详细阐述了联合电声刺激在改善动态范围、效率、空间分辨率和神经元选择性方面的潜在益处。
