Marjani Majid, Dolab Neda, Kamkar Mohammad Zaman, Amiriani Taghi, Yuzugulen Jale, Marjani Abdoljalal
Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, Turkey.
Student Research Committee, Department of Biochemistry and Biophysics, Gorgan Faculty of Medicine, Metabolic Disorders Research Center, Golestan University Medical Sciences, Gorgan, Iran.
Metab Syndr Relat Disord. 2022 Mar;20(2):79-87. doi: 10.1089/met.2021.0078. Epub 2021 Dec 7.
This is the study to assess alterations on adiponectin, leptin, and metabolic syndrome components in women and men bipolar disorder (BD) patients with normal weight and obesity who received valproic acid (VPA) and lithium (Li). Thirty-six women and 51 men were included. Commercial kits were used to determine all parameters. Metabolic syndrome components were determined according to the NCEP ATP III criteria. Patients who received Li and VPA significantly differ in waist circumference (WC) and triglyceride (TG) levels (in women and men). Normal weight patients received both drugs, significant differences were considered in high-density lipoprotein-cholesterol (HDL-C), WC, and TG levels compared to healthy controls, but there were significant differences in TG, leptin, and adiponectin levels in obese patients who received VPA. There were significant negative and positive correlation between leptin and adiponectin and WC and TG in women and men BD patients treated with VPA and Li. There were significant positive correlation between leptin and adiponectin and WC and TG and significant negative correlation with HDL-C in normal weight BD patients treated with VPA and Li, respectively, while there was only a significant positive correlation between leptin and adiponectin, and TG in obese BD patients treated with VPA. It looks like that patients treated with both drugs for our suggested time may increase leptin and adiponectin levels. Correlation differences between leptin and adiponectin, and metabolic syndrome components may be important parameters in women, men, normal weight, and obese BD patients. Monitoring of body composition and adipokines may benefit in medical care of these patients.
本研究旨在评估体重正常和肥胖的双相情感障碍（BD）女性和男性患者在接受丙戊酸（VPA）和锂盐（Li）治疗后脂联素、瘦素及代谢综合征各组分的变化。研究纳入了36名女性和51名男性。使用商用试剂盒测定所有参数。根据美国国家胆固醇教育计划成人治疗组第三次报告（NCEP ATP III）标准确定代谢综合征各组分。接受Li和VPA治疗的患者在腰围（WC）和甘油三酯（TG）水平上（无论女性还是男性）存在显著差异。体重正常的患者接受这两种药物治疗后，与健康对照相比，在高密度脂蛋白胆固醇（HDL-C）、WC和TG水平上存在显著差异，但接受VPA治疗的肥胖患者在TG、瘦素和脂联素水平上存在显著差异。在接受VPA和Li治疗的BD女性和男性患者中，瘦素与脂联素以及WC与TG之间存在显著的负相关和正相关。在接受VPA和Li治疗的体重正常的BD患者中，瘦素与脂联素以及WC与TG之间分别存在显著的正相关，与HDL-C存在显著的负相关，而在接受VPA治疗的肥胖BD患者中，瘦素与脂联素以及TG之间仅存在显著的正相关。看起来接受这两种药物治疗我们建议的时间后，患者可能会增加瘦素和脂联素水平。瘦素与脂联素以及代谢综合征各组分之间的相关性差异可能是BD女性、男性、体重正常和肥胖患者的重要参数。监测身体成分和脂肪因子可能有助于这些患者的医疗护理。
