Dolab Neda, Kamkar Mohammad Zaman, Amiriani Taghi, Yuzugulen Jale, Marjani Majid, Marjani Abdoljalal
Student Research Committee, Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Gorgan Faculty of Medicine, Golestan University Medical Sciences, Gorgan, Iran.
Department of Psychiatry, Golestan Research Center of Psychiatry, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran.
Heliyon. 2020 Jul 27;6(7):e04553. doi: 10.1016/j.heliyon.2020.e04553. eCollection 2020 Jul.
The aim of study is to assess a relation between the adiponectin and leptin levels, and metabolic syndrome components and lipid peroxidation treated with Li and VPA in bipolar disorder patients and compared with controls.
56 patients and 31 healthy controls were enrolled. The ATP III criteria were used to determine metabolic syndrome components. Leptin, adiponectin, lipid peroxidation and lipid profiles were measured.
Malondialdehyde in Li patients was higher than VPA patients. BMI, waist circumference (WC), triglyceride, malondialdehyde and adiponectin levels were increased, whereas HDL-cholesterol (VPA treated patients) and leptin were decreased in patients compared with controls. Leptin and adiponectin were correlated with WC, triglyceride and malondialdehyde in both groups. Adiponectin was correlated with HDL-cholesterol in VPA patients.
Patients should be checked metabolic syndrome components, serum leptin and adiponectin level occasionally to prevent possible deficiency or pathologic increase of these parameters.
本研究旨在评估双相情感障碍患者经锂盐和丙戊酸治疗后脂联素和瘦素水平、代谢综合征组分及脂质过氧化之间的关系，并与对照组进行比较。
招募了56例患者和31名健康对照。采用ATP III标准确定代谢综合征组分。检测瘦素、脂联素、脂质过氧化和血脂谱。
锂盐治疗患者的丙二醛水平高于丙戊酸治疗患者。与对照组相比，患者的体重指数、腰围（WC）、甘油三酯、丙二醛和脂联素水平升高，而高密度脂蛋白胆固醇（丙戊酸治疗患者）和瘦素降低。两组中瘦素和脂联素均与WC、甘油三酯和丙二醛相关。在丙戊酸治疗患者中，脂联素与高密度脂蛋白胆固醇相关。
应偶尔检查患者的代谢综合征组分、血清瘦素和脂联素水平，以预防这些参数可能出现的缺乏或病理性升高。
