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Rapid Phospholipid Turnover after Surfactant Nebulization in Severe COVID-19 Infection: A Randomized Clinical Trial.

作者信息

Postle Anthony D, Clark Howard W, Fink Jim, Madsen Jens, Koster Grielof, Panchal Madhuriben, Djukanovic Ratko, Brealey David, Grocott Michael P W, Dushianthan Ahilanandan

机构信息

University of Southampton Southampton, United Kingdom.

University Hospital Southampton National Health System Foundation Trust Southampton, United Kingdom.

出版信息

Am J Respir Crit Care Med. 2022 Feb 15;205(4):471-473. doi: 10.1164/rccm.202110-2279LE.

DOI:10.1164/rccm.202110-2279LE
PMID:34874818
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8886955/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a98/8886955/b0019d3f520d/rccm.202110-2279LEf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a98/8886955/b0019d3f520d/rccm.202110-2279LEf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a98/8886955/b0019d3f520d/rccm.202110-2279LEf1.jpg

相似文献

[1]
Rapid Phospholipid Turnover after Surfactant Nebulization in Severe COVID-19 Infection: A Randomized Clinical Trial.

Am J Respir Crit Care Med. 2022-2-15

[2]
Use of exogenous pulmonary surfactant in acute respiratory distress syndrome (ARDS): Role in SARS-CoV-2-related lung injury.

Respir Physiol Neurobiol. 2021-6

[3]
Surfactant alteration and replacement in acute respiratory distress syndrome.

Respir Res. 2001

[4]
Ultrasonic surfactant nebulization with different exciting frequencies.

Biophys Chem. 2000-2-14

[5]
Nebulized Poractant Alfa Reduces the Risk of Respiratory Failure at 72 Hours in Spontaneously Breathing Surfactant-Deficient Newborn Piglets.

Crit Care Med. 2020-6

[6]
Nebulization of Poractant alfa via a vibrating membrane nebulizer in spontaneously breathing preterm lambs with binasal continuous positive pressure ventilation.

Pediatr Res. 2015-12

[7]
Surfactant therapy for COVID-19 related ARDS: a retrospective case-control pilot study.

Respir Res. 2021-1-18

[8]
Supraglottic Atomization of Surfactant in Spontaneously Breathing Lambs Receiving Continuous Positive Airway Pressure.

Pediatr Crit Care Med. 2017-9

[9]
Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy.

Eur J Pharm Biopharm. 2020-12

[10]
Intratracheal atomized surfactant provides similar outcomes as bolus surfactant in preterm lambs with respiratory distress syndrome.

Pediatr Res. 2016-7

引用本文的文献

[1]
Lung Surfactant Deficiency in Severe Respiratory Failure: A Potential Biomarker for Clinical Assessment.

Diagnostics (Basel). 2025-3-26

[2]
Surfactant Phospholipid Kinetics in Ventilated Children after Therapeutic Surfactant Supplementation.

Int J Mol Sci. 2024-9-29

[3]
Oxidative stress, redox status and surfactant metabolism in mechanically ventilated patients receiving different approaches to oxygen therapy (MecROX): An observational study protocol for mechanistic evaluation.

NIHR Open Res. 2024-7-8

[4]
Effect of Surfactant Therapy on Clinical Outcomes of COVID-19 Patients With ARDS: A Systematic Review and Meta-Analysis.

Cureus. 2024-3-15

[5]
A randomized controlled trial of nebulized surfactant for the treatment of severe COVID-19 in adults (COVSurf trial).

Sci Rep. 2023-11-28

[6]
Alveolar Hyperoxia and Exacerbation of Lung Injury in Critically Ill SARS-CoV-2 Pneumonia.

Med Sci (Basel). 2023-11-1

[7]
Pulmonary Surfactant in Adult ARDS: Current Perspectives and Future Directions.

Diagnostics (Basel). 2023-9-15

[8]
Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19.

Am J Respir Crit Care Med. 2023-1-1

本文引用的文献

[1]
Breath-Synchronized Nebulized Surfactant in a Porcine Model of Acute Respiratory Distress Syndrome.

Crit Care Explor. 2021-2-15

[2]
Thoughts on the alveolar phase of COVID-19.

Am J Physiol Lung Cell Mol Physiol. 2020-6-3

[3]
Metabolism of a synthetic compared with a natural therapeutic pulmonary surfactant in adult mice.

J Lipid Res. 2018-8-14

[4]
Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers.

BMC Pulm Med. 2014-2-1

[5]
Exogenous surfactant may improve oxygenation but not mortality in adult patients with acute lung injury/acute respiratory distress syndrome: a meta-analysis of 9 clinical trials.

J Cardiothorac Vasc Anesth. 2012-1-20

[6]
Surfactant disaturated-phosphatidylcholine kinetics in acute respiratory distress syndrome by stable isotopes and a two compartment model.

Respir Res. 2007-2-21

[7]
Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome. Exosurf Acute Respiratory Distress Syndrome Sepsis Study Group.

N Engl J Med. 1996-5-30

[8]
Pharmacokinetics of bovine surfactant in neonatal respiratory distress syndrome.

Am J Respir Crit Care Med. 1995-9

[9]
The lecithin-sphingomyelin ratio of amniotic fluid: an index of fetal lung maturity?

Pediatrics. 1972-3

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