严重新型冠状病毒肺炎感染患者雾化吸入表面活性剂后的快速磷脂周转：一项随机临床试验 - Suppr

Rapid Phospholipid Turnover after Surfactant Nebulization in Severe COVID-19 Infection: A Randomized Clinical Trial.

作者信息

Postle Anthony D, Clark Howard W, Fink Jim, Madsen Jens, Koster Grielof, Panchal Madhuriben, Djukanovic Ratko, Brealey David, Grocott Michael P W, Dushianthan Ahilanandan

机构信息

University of Southampton Southampton, United Kingdom.

University Hospital Southampton National Health System Foundation Trust Southampton, United Kingdom.

出版信息

Am J Respir Crit Care Med. 2022 Feb 15;205(4):471-473. doi: 10.1164/rccm.202110-2279LE.

DOI:10.1164/rccm.202110-2279LE

PMID:34874818

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8886955/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a98/8886955/b0019d3f520d/rccm.202110-2279LEf1.jpg

相似文献

Rapid Phospholipid Turnover after Surfactant Nebulization in Severe COVID-19 Infection: A Randomized Clinical Trial.

Am J Respir Crit Care Med. 2022 Feb 15;205(4):471-473. doi: 10.1164/rccm.202110-2279LE.

Use of exogenous pulmonary surfactant in acute respiratory distress syndrome (ARDS): Role in SARS-CoV-2-related lung injury.

Respir Physiol Neurobiol. 2021 Jun;288:103645. doi: 10.1016/j.resp.2021.103645. Epub 2021 Feb 28.

Surfactant alteration and replacement in acute respiratory distress syndrome.

Respir Res. 2001;2(6):353-64. doi: 10.1186/rr86. Epub 2001 Oct 12.

Ultrasonic surfactant nebulization with different exciting frequencies.

Biophys Chem. 2000 Feb 14;84(1):35-43. doi: 10.1016/s0301-4622(99)00144-1.

Nebulized Poractant Alfa Reduces the Risk of Respiratory Failure at 72 Hours in Spontaneously Breathing Surfactant-Deficient Newborn Piglets.

Crit Care Med. 2020 Jun;48(6):e523-e531. doi: 10.1097/CCM.0000000000004318.

Nebulization of Poractant alfa via a vibrating membrane nebulizer in spontaneously breathing preterm lambs with binasal continuous positive pressure ventilation.

Pediatr Res. 2015 Dec;78(6):664-9. doi: 10.1038/pr.2015.165. Epub 2015 Aug 31.

Surfactant therapy for COVID-19 related ARDS: a retrospective case-control pilot study.

Respir Res. 2021 Jan 18;22(1):20. doi: 10.1186/s12931-020-01603-w.

Supraglottic Atomization of Surfactant in Spontaneously Breathing Lambs Receiving Continuous Positive Airway Pressure.

Pediatr Crit Care Med. 2017 Sep;18(9):e428-e434. doi: 10.1097/PCC.0000000000001267.

Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy.

Eur J Pharm Biopharm. 2020 Dec;157:191-199. doi: 10.1016/j.ejpb.2020.09.011. Epub 2020 Oct 3.

Intratracheal atomized surfactant provides similar outcomes as bolus surfactant in preterm lambs with respiratory distress syndrome.

Pediatr Res. 2016 Jul;80(1):92-100. doi: 10.1038/pr.2016.39. Epub 2016 Mar 8.

引用本文的文献

Lung Surfactant Deficiency in Severe Respiratory Failure: A Potential Biomarker for Clinical Assessment.

Diagnostics (Basel). 2025 Mar 26;15(7):847. doi: 10.3390/diagnostics15070847.

Surfactant Phospholipid Kinetics in Ventilated Children after Therapeutic Surfactant Supplementation.

Int J Mol Sci. 2024 Sep 29;25(19):10480. doi: 10.3390/ijms251910480.

Oxidative stress, redox status and surfactant metabolism in mechanically ventilated patients receiving different approaches to oxygen therapy (MecROX): An observational study protocol for mechanistic evaluation.

NIHR Open Res. 2024 Jul 8;4:23. doi: 10.3310/nihropenres.13567.2. eCollection 2024.

Effect of Surfactant Therapy on Clinical Outcomes of COVID-19 Patients With ARDS: A Systematic Review and Meta-Analysis.

Cureus. 2024 Mar 15;16(3):e56238. doi: 10.7759/cureus.56238. eCollection 2024 Mar.

A randomized controlled trial of nebulized surfactant for the treatment of severe COVID-19 in adults (COVSurf trial).

Sci Rep. 2023 Nov 28;13(1):20946. doi: 10.1038/s41598-023-47672-x.

Alveolar Hyperoxia and Exacerbation of Lung Injury in Critically Ill SARS-CoV-2 Pneumonia.

Med Sci (Basel). 2023 Nov 1;11(4):70. doi: 10.3390/medsci11040070.

Pulmonary Surfactant in Adult ARDS: Current Perspectives and Future Directions.

Diagnostics (Basel). 2023 Sep 15;13(18):2964. doi: 10.3390/diagnostics13182964.

Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19.

Am J Respir Crit Care Med. 2023 Jan 1;207(1):38-49. doi: 10.1164/rccm.202201-0011OC.

本文引用的文献

Breath-Synchronized Nebulized Surfactant in a Porcine Model of Acute Respiratory Distress Syndrome.

Crit Care Explor. 2021 Feb 15;3(2):e0338. doi: 10.1097/CCE.0000000000000338. eCollection 2021 Feb.

Thoughts on the alveolar phase of COVID-19.

Am J Physiol Lung Cell Mol Physiol. 2020 Jul 1;319(1):L115-L120. doi: 10.1152/ajplung.00126.2020. Epub 2020 Jun 3.

Metabolism of a synthetic compared with a natural therapeutic pulmonary surfactant in adult mice.

J Lipid Res. 2018 Oct;59(10):1880-1892. doi: 10.1194/jlr.M085431. Epub 2018 Aug 14.

Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers.

BMC Pulm Med. 2014 Feb 1;14:10. doi: 10.1186/1471-2466-14-10.

Exogenous surfactant may improve oxygenation but not mortality in adult patients with acute lung injury/acute respiratory distress syndrome: a meta-analysis of 9 clinical trials.

J Cardiothorac Vasc Anesth. 2012 Oct;26(5):849-56. doi: 10.1053/j.jvca.2011.11.006. Epub 2012 Jan 20.

Surfactant disaturated-phosphatidylcholine kinetics in acute respiratory distress syndrome by stable isotopes and a two compartment model.

Respir Res. 2007 Feb 21;8(1):13. doi: 10.1186/1465-9921-8-13.

Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome. Exosurf Acute Respiratory Distress Syndrome Sepsis Study Group.

N Engl J Med. 1996 May 30;334(22):1417-21. doi: 10.1056/NEJM199605303342201.

Pharmacokinetics of bovine surfactant in neonatal respiratory distress syndrome.

Am J Respir Crit Care Med. 1995 Sep;152(3):1050-4. doi: 10.1164/ajrccm.152.3.7663782.

The lecithin-sphingomyelin ratio of amniotic fluid: an index of fetal lung maturity?

Pediatrics. 1972 Mar;49(3):464-7.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Rapid Phospholipid Turnover after Surfactant Nebulization in Severe COVID-19 Infection: A Randomized Clinical Trial.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献