Melbourne Sexual Health Centre, Alfred Health, Melbourne, Australia.
Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
JMIR Public Health Surveill. 2021 Dec 6;7(12):e32407. doi: 10.2196/32407.
Men who have sex with men are a risk group for anal human papillomavirus (HPV) and anal cancer. Australia introduced a universal school-based HPV vaccination program in 2013. Self-reported HPV vaccination status has been widely used in clinical and research settings, but its accuracy is understudied.
We aimed to examine the accuracy of self-reported HPV vaccination status among gay and bisexual adolescent males.
We included 192 gay and bisexual males aged 16-20 years from the Human Papillomavirus in Young People Epidemiological Research 2 (HYPER2) study in Melbourne, Australia. All participants had been eligible for the universal school-based HPV vaccination program implemented in 2013 and were asked to self-report their HPV vaccination status. Written informed consent was obtained to verify their HPV vaccination status using records at the National HPV Vaccination Program Register and the Australian Immunisation Register. We calculated the sensitivity, specificity, positive predictive value, and negative predictive value of self-reported HPV vaccination status.
The median age of the 192 males was 19 (IQR 18-20) years. There were 128 males (67%) who had HPV vaccination records documented on either registry. Self-reported HPV vaccination had a sensitivity of 47.7% (95% CI 38.8%-56.7%; 61/128), a specificity of 85.9% (95% CI 75.0%-93.4%; 55/64), a positive predictive value of 87.1% (95% CI 77.0%-93.9%; 61/70), and a negative predictive value of 45.1% (95% CI 36.1%-54.3%; 55/122).
Self-reported HPV vaccination status among Australian gay and bisexual adolescent males underestimates actual vaccination and may be inaccurate for clinical and research purposes.
男男性行为者是肛门人乳头瘤病毒（HPV）和肛门癌的高危人群。澳大利亚于 2013 年推出了一项普及型学校 HPV 疫苗接种计划。自我报告的 HPV 疫苗接种状况已广泛用于临床和研究环境，但准确性研究不足。
我们旨在检验男同性恋和双性恋青少年男性自我报告的 HPV 疫苗接种状况的准确性。
我们纳入了澳大利亚墨尔本 HPV 对年轻人的流行病学研究 2（HYPER2）研究中的 192 名 16-20 岁的男同性恋和双性恋男性。所有参与者都符合 2013 年实施的普及型学校 HPV 疫苗接种计划的条件，并被要求自我报告 HPV 疫苗接种状况。通过国家 HPV 疫苗接种计划登记处和澳大利亚免疫登记处的记录，获得书面知情同意，以核实他们的 HPV 疫苗接种状况。我们计算了自我报告的 HPV 疫苗接种状况的敏感性、特异性、阳性预测值和阴性预测值。
192 名男性的中位年龄为 19（IQR 18-20）岁。有 128 名男性（67%）在两个登记处都有 HPV 疫苗接种记录。自我报告的 HPV 疫苗接种的敏感性为 47.7%（95%CI 38.8%-56.7%；61/128），特异性为 85.9%（95%CI 75.0%-93.4%；55/64），阳性预测值为 87.1%（95%CI 77.0%-93.9%；61/70），阴性预测值为 45.1%（95%CI 36.1%-54.3%；55/122）。
澳大利亚男同性恋和双性恋青少年男性自我报告的 HPV 疫苗接种状况低估了实际接种情况，在临床和研究中可能不准确。
