2016年至2018年华盛顿州西雅图市18至26岁男男性行为者自我报告的人乳头瘤病毒疫苗接种史的敏感性
Sensitivity of Self-Reported Human Papillomavirus Vaccination History Among 18- to 26-Year-Old Men Who Have Sex With Men: Seattle, WA, 2016 to 2018.
作者信息
Forward Terra, Meites Elissa, Lin John, Hughes James P, Unger Elizabeth R, Markowitz Lauri E, Golden Matthew, Swanson Fred, Faestel Paul M, Winer Rachel L
机构信息
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA.
From the Department of Epidemiology, University of Washington School of Public Health, Seattle.
出版信息
Sex Transm Dis. 2022 Jan 1;49(1):81-85. doi: 10.1097/OLQ.0000000000001503.
BACKGROUND
We assessed the sensitivity of self-reported human papillomavirus (HPV) vaccination among young adult men who have sex with men (MSM) with documented HPV vaccination.
METHODS
During 2016-2018, MSM and transgender women aged 18 to 26 years were enrolled in Seattle, WA. A history of HPV vaccination was assessed via self-administered survey, clinic electronic medical records, and the Washington State Immunization Information System. We assessed self-report sensitivity among participants with documented prior HPV vaccination (≥1 dose) in either the electronic medical record or the Washington State Immunization Information System, and used logistic regression to compare sensitivity by age, number of doses, and time since first dose.
RESULTS
Of 292 participants with ≥1 documented HPV vaccine dose, 243 self-reported ≥1 dose (sensitivity, 83.2%; 95% confidence interval [CI], 78.4%-87.3%). Compared with participants whose first dose was <1 year ago, the likelihood of self-report was lower among those with ≥3 years since first dose (adjusted odds ratio [aOR], 0.2; 95% CI, 0.1-0.5). Furthermore, compared with participants with only 1 documented HPV vaccine dose, the likelihood of self-reporting ≥1 dose was higher among those with 2 (aOR, 2.4; 95% CI, 1.0-5.5) or ≥3 doses (aOR, 6.2; 95% CI, 2.7-14.4). Among 115 participants with ≥3 documented doses, sensitivity for recalling ≥3 doses was 69.6% (95% CI, 60.3%-77.8%).
CONCLUSIONS
Most young adult MSM with a documented history of HPV vaccination self-reported prior HPV vaccination. Although recall was highest in those with ≥3 doses, 30% of this fully vaccinated subgroup did not correctly recall the number of doses received, highlighting limitations of self-reporting. Furthermore, results indicating reduced recall with ≥3 years since first dose suggest that sensitivity of self-report among young adult MSM may decline over time as adolescent vaccination coverage increases.
背景
我们评估了有HPV疫苗接种记录的男男性行为者（MSM）中，自我报告的HPV疫苗接种情况的敏感性。
方法
在2016 - 2018年期间，华盛顿州西雅图市招募了年龄在18至26岁的男男性行为者和跨性别女性。通过自行填写的调查问卷、诊所电子病历以及华盛顿州免疫信息系统来评估HPV疫苗接种史。我们评估了在电子病历或华盛顿州免疫信息系统中有既往HPV疫苗接种记录（≥1剂）的参与者的自我报告敏感性，并使用逻辑回归分析按年龄、接种剂数和首次接种后的时间来比较敏感性。
结果
在292名有≥1剂HPV疫苗接种记录的参与者中，243人自我报告接种了≥1剂（敏感性为83.2%；95%置信区间[CI]，78.4% - 87.3%）。与首次接种时间<1年前的参与者相比，首次接种时间≥3年的参与者自我报告的可能性较低（调整后的优势比[aOR]为0.2；95% CI，0.1 - 0.5）。此外，与仅有1剂HPV疫苗接种记录的参与者相比，接种2剂（aOR为2.4；95% CI，1.0 - 5.5）或≥3剂（aOR为6.2；95% CI，2.7 - 14.4）的参与者自我报告接种≥1剂的可能性更高。在115名有≥3剂接种记录的参与者中，回忆起≥3剂的敏感性为69.6%（95% CI，60.3% - 77.8%）。
结论
大多数有HPV疫苗接种记录的年轻成年男男性行为者自我报告了既往HPV疫苗接种情况。尽管接种≥3剂者的回忆率最高，但该完全接种亚组中有30%的人未正确回忆起接种的剂数，这凸显了自我报告的局限性。此外，结果表明首次接种≥3年后回忆率降低，这表明随着青少年疫苗接种覆盖率的提高，年轻成年男男性行为者中自我报告的敏感性可能会随时间下降。
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