Department of Population Health, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD, 4006, Australia.
Faculty of Medicine, University of Queensland, Brisbane, Australia.
Cancer Causes Control. 2023 Sep;34(9):785-789. doi: 10.1007/s10552-023-01729-4. Epub 2023 May 31.
Australia has a school-based human papillomavirus (HPV) vaccination scheme that was implemented for girls in 2007 and for boys in 2013. HPV vaccination status is important for many studies into HPV infection. Here we wanted to estimate the validity of self-reported HPV vaccination status by comparing self-report to data from the national vaccination register.
Australian residents aged 18-70 years were recruited for the Oral Diversity Study from October 2020 to November 2021. Participants were asked to provide consent for record linkage to the Australian Immunisation Register (AIR). They were also asked to fill out a questionnaire about HPV vaccination, lifestyle, and sexual behavior.
1,023 participants were recruited, permission was received from 911 participants for HPV vaccination record linkage, and 850 self-reported vaccination and were part of the validity analysis. Of those 233 (26%) were confirmed to be HPV vaccinated. Ninety-one percent of the vaccinated were females (n = 212), 19 males and two non-binary. The highest HPV vaccine uptake was seen in the youngest age group (18-29 years; 80%), followed by 66% in 30-39 year olds, 2% in 40-49 year olds and then dropped significantly to 0.7% for people 50-70 years old. The sensitivity of self-report was 99.0%, and the specificity 94.5%, and the positive predictive value was 85.7% and the negative predictive value 99.7%.
We found that the correlation between self-reported Gardasil® vaccination and the AIR records were very good, with high sensitivity and specificity.
澳大利亚实施了一项基于学校的人乳头瘤病毒（HPV）疫苗接种计划，该计划于 2007 年为女孩接种，于 2013 年为男孩接种。HPV 疫苗接种状况对于许多 HPV 感染研究非常重要。在这里，我们希望通过将自我报告的 HPV 疫苗接种状况与国家疫苗接种登记处的数据进行比较，来评估自我报告的 HPV 疫苗接种状况的有效性。
从 2020 年 10 月至 2021 年 11 月，澳大利亚居民年龄在 18-70 岁之间被招募参加口腔多样性研究。要求参与者同意将其记录与澳大利亚免疫登记处（AIR）进行链接。他们还被要求填写一份关于 HPV 疫苗接种、生活方式和性行为的问卷。
共招募了 1023 名参与者，911 名参与者同意 HPV 疫苗接种记录链接，850 名自我报告接种疫苗的参与者参与了有效性分析。其中 233 名（26%）被确认为 HPV 接种者。91%的接种者为女性（n=212），19 名男性和 2 名非二进制性别。年龄最小的 18-29 岁组 HPV 疫苗接种率最高（80%），其次是 30-39 岁组的 66%，40-49 岁组的 2%，50-70 岁组的接种率显著下降至 0.7%。自我报告的敏感性为 99.0%，特异性为 94.5%，阳性预测值为 85.7%，阴性预测值为 99.7%。
我们发现自我报告的佳达修®疫苗接种与 AIR 记录之间的相关性非常好，具有很高的敏感性和特异性。
