人乳基强化剂与牛乳基强化剂相比，较少改变乳脂肪球大小。
Human milk-based fortifier is associated with less alteration of milk fat globule size than cow milk-based fortifier.
机构信息
Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
Department of Pediatrics, Dell Medical School, Dell Pediatric Research Institute, University of Texas at Austin, Austin, Texas.
出版信息
PLoS One. 2021 Dec 7;16(12):e0257491. doi: 10.1371/journal.pone.0257491. eCollection 2021.
We aimed to evaluate if human milk-based fortifier (HMBF) affects human milk fat globule (MFG) size less than cow milk-based fortifier (CMBF), which may impact overall infant feeding tolerance. Measurements of donated human milk were performed before fortification as well as at 1 hour, 24 hours, and 48 hours after fortification with CMBF or HMBF. MFG size in each sample of fortified milk was measured by laser light scattering. MFG size in the fortified milks increased gradually over time. At 24 and 48 hours after fortification, MFG size in the milk with CMBF was larger than that in the milk with HMBF (4.8 ± 0.5 vs 4.3 ± 0.3 μm, p<0.01, 5.1 ± 0.7 vs 4.5 ± 0.4 μm, p = 0.03, respectively). HMBF is associated with less alteration of MFG size than CMBF. This may have an impact on feeding tolerance of very preterm infants.
我们旨在评估人乳强化剂（HMBF）是否比牛乳强化剂（CMBF）对人乳脂肪球（MFG）大小的影响更小，这可能会影响整体婴儿喂养耐受性。在强化之前以及强化后 1 小时、24 小时和 48 小时，对捐赠的人乳进行了测量。通过激光光散射测量强化奶中每个样本的 MFG 大小。MFG 大小在强化奶中随时间逐渐增加。在强化后 24 小时和 48 小时时，CMBF 强化奶中的 MFG 大小大于 HMBF 强化奶中的 MFG 大小（4.8±0.5 对 4.3±0.3 μm，p<0.01；5.1±0.7 对 4.5±0.4 μm，p=0.03）。HMBF 与人乳强化剂相比，对 MFG 大小的改变较小。这可能会对极早产儿的喂养耐受性产生影响。
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