2019冠状病毒病患者抗1型干扰素自身抗体的时间动态变化
Temporal Dynamics of Anti-Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019.
作者信息
Shaw Elana R, Rosen Lindsey B, Cheng Aristine, Dobbs Kerry, Delmonte Ottavia M, Ferré Elise M N, Schmitt Monica M, Imberti Luisa, Quaresima Virginia, Lionakis Michail S, Notarangelo Luigi D, Holland Steven M, Su Helen C
机构信息
Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Infectious Diseases Division, Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
出版信息
Clin Infect Dis. 2022 Aug 24;75(1):e1192-e1194. doi: 10.1093/cid/ciab1002.
Binding levels and neutralization activity of anti-type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals before the development of critical viral disease may be challenging.
抗1型干扰素自身抗体的结合水平和中和活性在新型冠状病毒肺炎急性期达到峰值，此后显著下降。尽管结合免疫球蛋白G水平较低，但大多数患者在恢复期仍保持一定的中和1型干扰素的能力。在严重病毒性疾病发生之前在健康个体中识别这些自身抗体可能具有挑战性。
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