Diaz-Canestro Candela, Pentz Brandon, Sehgal Arshia, Montero David
Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada.
Appl Physiol Nutr Metab. 2022 Jan;47(1):75-82. doi: 10.1139/apnm-2021-0196. Epub 2021 Dec 8.
Blood donation entails acute reductions of cardiorespiratory fitness in healthy men. Whether these effects can be extrapolated to blood donor populations comprising women remains uncertain. The purpose of this study was to comprehensively assess the acute impact of blood withdrawal on cardiac function, central hemodynamics and aerobic capacity in women throughout the mature adult lifespan. Transthoracic echocardiography and O uptake were assessed at rest and throughout incremental exercise (cycle ergometry) in healthy women ( = 30, age: 47-77 yr). Left ventricular end-diastolic volume (LVEDV), stroke volume (SV), cardiac output () and peak O uptake (O), and blood volume (BV) were determined with established methods. Measurements were repeated following a 10% reduction of BV within a week period. Individuals were non-smokers, non-obese and moderately fit (O = 31.4 ± 7.3 mL·min·kg). Hematocrit and BV ranged from 38.0 to 44.8% and from 3.8 to 6.6 L, respectively. The standard 10% reduction in BV resulted in 0.5 ± 0.1 L withdrawal of blood, which did not alter hematocrit ( = 0.953). Blood withdrawal substantially reduced cardiac LVEDV and SV at rest as well as during incremental exercise (≥10% decrements, ≤ 0.009). Peak was proportionally decreased after blood withdrawal ( < 0.001). Blood withdrawal induced a 10% decrement in O ( < 0.001). In conclusion, blood withdrawal impairs cardiac filling, and aerobic capacity in proportion to the magnitude of hypovolemia in healthy mature women. The filling of the heart and therefore cardiac output are impaired by blood withdrawal in women. Oxygen delivery and aerobic capacity are reduced in proportion to blood withdrawal.
献血会使健康男性的心肺功能急剧下降。这些影响是否能外推至包括女性在内的献血人群仍不确定。本研究的目的是全面评估采血对成年女性整个成熟生命周期中心脏功能、中心血流动力学和有氧能力的急性影响。对30名健康女性（年龄：47 - 77岁）在静息状态及递增运动（蹬车测力法）过程中进行经胸超声心动图检查和摄氧量评估。采用既定方法测定左心室舒张末期容积（LVEDV）、每搏输出量（SV）、心输出量（CO）、峰值摄氧量（VO₂）和血容量（BV）。在一周内将BV降低10%后重复测量。研究对象为不吸烟、非肥胖且中度健康（VO₂ = 31.4 ± 7.3 mL·min·kg）的个体。血细胞比容和BV分别为38.0%至44.8%和3.8至6.6 L。标准的10% BV降低导致采血0.5 ± 0.1 L，这并未改变血细胞比容（P = 0.953）。采血显著降低了静息状态及递增运动过程中的心脏LVEDV和SV（降低≥10%，P≤ = 0.009）。采血后峰值VO₂成比例下降（P < 0.001）。采血导致VO₂下降10%（P < 0.001）。总之采血会损害健康成熟女性的心脏充盈、心输出量和有氧能力。女性采血会损害心脏充盈进而损害心输出量。氧输送和有氧能力会随着采血成比例降低。
