Varlı Bulut, Şükür Yavuz Emre, Özmen Batuhan, Ergüder Berrin İmge, Sönmezer Murat, Berker Bülent, Atabekoğlu Cem, Aytaç Ruşen
Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University, Ankara, Turkey.
Department of Biochemistry, Faculty of Medicine, Ankara University, Ankara, Turkey.
Clin Exp Reprod Med. 2021 Dec;48(4):368-373. doi: 10.5653/cerm.2021.04420. Epub 2021 Nov 30.
In this study we aimed to assess anorexigenic peptide levels in patients with or without polycystic ovary syndrome (PCOS) and their effects on assisted reproductive treatment (ART) outcomes.
A prospective case-control study was conducted in a tertiary care university-based ART clinic. Eighty-three patients were included in the study. The PCOS group included 41 patients, and the non-PCOS group included 42 controls. The 2003 Rotterdam criteria were used for PCOS patient selection. The ART indications in the non-PCOS group were tubal factor or unexplained infertility. Venous blood samples were taken on the third day of the menstrual cycle to determine the serum anorexigenic peptide levels. The enzyme-linked immunosorbent assay method was used for laboratory analyses.
In the PCOS group, serum obestatin levels were significantly lower than in the control group, but serum anorexigenic peptide levels were similar in PCOS patients with or without clinical pregnancy. Ovarian hyperstimulation syndrome (OHSS) was diagnosed only in PCOS patients, and the obestatin levels of OHSS patients were significantly lower than those of other PCOS patients.
Baseline anorexigenic peptide levels did not affect the clinical pregnancy rate in ART cycles. Obestatin may play a role in the pathophysiology of OHSS. This possibility should be confirmed in further research.
在本研究中，我们旨在评估患有或未患有多囊卵巢综合征（PCOS）的患者体内的厌食性肽水平及其对辅助生殖治疗（ART）结局的影响。
在一家基于大学的三级护理ART诊所进行了一项前瞻性病例对照研究。83名患者被纳入研究。PCOS组包括41名患者，非PCOS组包括42名对照。采用2003年鹿特丹标准选择PCOS患者。非PCOS组的ART指征为输卵管因素或不明原因的不孕症。在月经周期的第三天采集静脉血样以测定血清厌食性肽水平。实验室分析采用酶联免疫吸附测定法。
在PCOS组中，血清肥胖抑制素水平显著低于对照组，但有或无临床妊娠的PCOS患者的血清厌食性肽水平相似。仅在PCOS患者中诊断出卵巢过度刺激综合征（OHSS），OHSS患者的肥胖抑制素水平显著低于其他PCOS患者。
基线厌食性肽水平不影响ART周期中的临床妊娠率。肥胖抑制素可能在OHSS的病理生理学中起作用。这一可能性应在进一步研究中得到证实。
