Ademoglu Esra Nur, Gorar Suheyla, Carlıoglu Ayse, Yazıcı Havva, Dellal Fatma Dilek, Berberoglu Zehra, Akdeniz Derya, Uysal Sema, Karakurt Feridun
Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey.
Department of Endocrinology and Metabolism, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.
J Endocrinol Invest. 2014 Aug;37(8):715-719. doi: 10.1007/s40618-014-0089-2. Epub 2014 Jun 12.
Nesfatin-1 is a recently discovered neuropeptide derived from its precursor nucleobindin-2 (NUCB2) and has been implicated in the regulation of feeding and energy metabolism. It is located in the brain and also produced at the periphery and present in the plasma. However, its pathophysiological role in humans remains unknown. Polycystic ovary syndrome (PCOS) is commonly presented with obesity, insulin resistance, hyperandrogenemia and hirsutism.
To characterize serum nesfatin-1 levels in PCOS women and determine association of nesfatin-1 with metabolic parameters.
It is a cross-sectional study of 55 PCOS and 28 healthy women matched in age, in a university hospital setting. Anthropometric, hormonal, metabolic parameters and nesfatin-1 blood levels were determined.
Nesfatin-1 levels were significantly higher in PCOS group compared with the controls 371.43 ± 2.50 versus 275.55 ± 1.74 pg/mL. Multivariate logistic regression analysis that contains: nesfatin-1, body mass index and homeostasis model assessment index revealed significant correlation of nesfatin-1 with the existence of PCOS (p < 0.05).
Higher nesfatin-1 levels in PCOS women compared to control group may suggest a possibility that nesfatin-1 may play some role in the PCOS.
Nesfatin-1是一种最近发现的神经肽，由其前体核结合蛋白-2（NUCB2）衍生而来，与进食和能量代谢的调节有关。它位于大脑中，也在外周产生并存在于血浆中。然而，其在人类中的病理生理作用尚不清楚。多囊卵巢综合征（PCOS）通常表现为肥胖、胰岛素抵抗、高雄激素血症和多毛症。
描述PCOS女性血清nesfatin-1水平，并确定nesfatin-1与代谢参数的关联。
这是一项在大学医院环境中对55名PCOS患者和28名年龄匹配的健康女性进行的横断面研究。测定了人体测量学、激素、代谢参数和nesfatin-1血水平。
PCOS组的nesfatin-1水平显著高于对照组，分别为371.43±2.50 pg/mL和275.55±1.74 pg/mL。包含nesfatin-1、体重指数和稳态模型评估指数的多因素逻辑回归分析显示nesfatin-1与PCOS的存在显著相关（p<0.05）。
与对照组相比，PCOS女性中较高的nesfatin-1水平可能表明nesfatin-1可能在PCOS中发挥某种作用。
