Faculty of Public Health, Al Quds University, Abu Dis Campus, Jerusalem, Palestine.
Nutr Cancer. 2022;74(7):2460-2469. doi: 10.1080/01635581.2021.2013507. Epub 2021 Dec 8.
To add evidence to the limited data available on colorectal cancer (CRC) from Palestine, we examine the risk factors associated with CRC using a matched hospital-based case-control study. A structured questionnaire was used to collect data from 105 cases and 105 controls. A multivariable conditional regression model was used to adjust for the association between study factors and CRC risk. In the model, compared with controls, cases from villages were significantly less likely to have CRC (Adjusted Odds Ratio, AOR = 0.194); taking aspirin lowered the likelihood of CRC by 24%; and having a multiple birth sibling by 33%. Also, the likelihood of CRC was lowered significantly by consuming five servings of fruits/vegetables per week or more (5-6 servings: AOR = 0.21, 7-8 servings per week: AOR = 0.04). However, cases had a significantly higher likelihood of CRC if they consumed 2-4 servings of grilled red meat per week (AOR = 4.25); smoked (AOR = 4.38); had a sedentary lifestyle (AOR = 2.53); reported parental consanguinity (AOR = 3.88); or had a family history of cancer (AOR = 6.39). Our results confirmed the association between CRC and red meat intake and smoking, and proved that parental consanguinity and family history of cancer are also risk factors for CRC.
为了为巴勒斯坦有限的结直肠癌（CRC）数据提供证据，我们使用基于医院的病例对照研究来检查与 CRC 相关的危险因素。使用结构化问卷从 105 例病例和 105 例对照中收集数据。使用多变量条件回归模型调整研究因素与 CRC 风险之间的关联。在模型中，与对照组相比，来自村庄的病例发生 CRC 的可能性显著降低（调整后的优势比，AOR = 0.194）；服用阿司匹林可使 CRC 的可能性降低 24%；有多个同胞兄弟姐妹可使 CRC 的可能性降低 33%。此外，如果每周食用五份或更多份水果/蔬菜（5-6 份：AOR = 0.21，每周 7-8 份：AOR = 0.04），则 CRC 的可能性也会显著降低。然而，如果每周食用 2-4 份烤红肉（AOR = 4.25）、吸烟（AOR = 4.38）、生活方式久坐（AOR = 2.53）、报告父母近亲结婚（AOR = 3.88）或有癌症家族史（AOR = 6.39），则病例发生 CRC 的可能性显著增加。我们的结果证实了 CRC 与红肉摄入和吸烟之间的关联，并证明了父母近亲结婚和癌症家族史也是 CRC 的危险因素。
