Liao Zhiyuan, Wu Wenjiang, Xia Shijun, Yu Linchong, Xu Zhigang, Li Yue
Shenzhen Hospital (Fu Tian) of Guangzhou University of Chinese Medicine, Shenzhen, China.
Front Med (Lausanne). 2025 Jun 9;12:1555717. doi: 10.3389/fmed.2025.1555717. eCollection 2025.
This study aimed to evaluate the correlation between the consumption of red meat and processed meat and the incidence of colorectal cancer (CRC) in Asia and provide a scientific basis for reducing the incidence of CRC.
PubMed, Embase, Cochrane Library, and other databases were searched electronically to collect studies on the correlation between the consumption of red meat and processed meat and the incidence of CRC in Asia. After the quality evaluation of the Newcastle-Ottawa scale, meta-analyses of the selected studies were performed using RevMan 5.4.1. The odds ratio (OR) and 95% confidence interval (95% CI) were combined, and the heterogeneity among the included studies was analyzed via sensitivity analysis. was used to evaluate the heterogeneity among the included studies.
Twelve articles were included, which involved 13,292 and 12,544 cases in the case and control groups, respectively. The results of the meta-analysis revealed that in the study of the correlation between the consumption of red meat and the incidence of colon cancer, the combined OR was 2.14 ( < 0.00001); that for the consumption of red meat and the incidence of CRC, the OR was 1.77 ( = 0.006); that for the consumption of red meat and the incidence of rectal cancer, the OR was 2.42 ( = 0.0009); and that for the consumption of processed meat and the incidence of CRC, the combined OR was 1.51 ( > 0.05).
The results suggest that red meat is a risk factor for the incidence of colon, colorectal, and rectal cancers. However, no significant correlation was found between the consumption of processed meat and the incidence of CRC.
本研究旨在评估亚洲地区红肉和加工肉类的消费量与结直肠癌（CRC）发病率之间的相关性，为降低结直肠癌发病率提供科学依据。
通过电子检索PubMed、Embase、Cochrane图书馆等数据库，收集亚洲地区红肉和加工肉类消费量与结直肠癌发病率相关性的研究。采用纽卡斯尔-渥太华量表进行质量评估后，使用RevMan 5.4.1对入选研究进行荟萃分析。合并比值比（OR）和95%置信区间（95%CI），并通过敏感性分析评估纳入研究之间的异质性。 用于评估纳入研究之间的异质性。
纳入12篇文章，病例组和对照组分别涉及13292例和12544例。荟萃分析结果显示，在红肉消费量与结肠癌发病率相关性研究中,合并OR为2.14（<0.00001）；红肉消费量与结直肠癌发病率相关性研究中，OR为1.77（=0.006）；红肉消费量与直肠癌发病率相关性研究中，OR为2.42（=0.0009）；加工肉类消费量与结直肠癌发病率相关性研究中，合并OR为1.51（>0.05）。
结果表明，红肉是结肠癌、结直肠癌和直肠癌发病的危险因素。然而，未发现加工肉类消费量与结直肠癌发病率之间存在显著相关性。
