Hu Dingyu, Shao Wenjun, Liu Li, Wang Yanyan, Yuan Shunling, Liu Zhaoping, Liu Jing, Zhang Ji
The First Affiliated Hospital, Department of Rheumatology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Hunan Province Key Laboratory of Basic and Applied Hematology, Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, China.
Cancer Cell Int. 2021 Dec 7;21(1):653. doi: 10.1186/s12935-021-02362-4.
MYB is often overexpressed in malignant tumors and plays a carcinogenic role in the initiation and development of cancer. Deletion of the MYB regulatory C-terminal domain may be a driving mutation leading to tumorigenesis, therefore, different tumor mechanisms produce similar MYB proteins. As MYB is a transcription factor, priority has been given to identifying the genes that it regulates. All previous attention has been focused on protein-coding genes. However, an increasing number of studies have suggested that MYB can affect the complexity of cancer progression by regulating tumor-associated noncoding RNAs (ncRNAs), such as microRNAs, long-non-coding RNAs and circular RNAs. ncRNAs can regulate the expression of numerous downstream genes at the transcription, RNA processing and translation levels, thereby having various biological functions. Additionally, ncRNAs play important roles in regulating MYB expression. This review focuses on the intricate crosstalk between oncogenic MYB and ncRNAs, which play a pivotal role in tumorigenesis, including proliferation, apoptosis, angiogenesis, metastasis, senescence and drug resistance. In addition, we discuss therapeutic strategies for crosstalk between MYB and ncRNAs to prevent the occurrence and development of cancer.
MYB在恶性肿瘤中常过度表达，并在癌症的发生和发展中发挥致癌作用。MYB调控性C末端结构域的缺失可能是导致肿瘤发生的驱动性突变，因此，不同的肿瘤机制产生相似的MYB蛋白。由于MYB是一种转录因子，此前一直优先致力于鉴定其调控的基因。以往所有的关注都集中在蛋白质编码基因上。然而，越来越多的研究表明，MYB可通过调控肿瘤相关的非编码RNA（ncRNA），如微小RNA、长链非编码RNA和环状RNA，来影响癌症进展的复杂性。ncRNA可在转录、RNA加工和翻译水平调控众多下游基因的表达，从而具有多种生物学功能。此外，ncRNA在调控MYB表达中也发挥重要作用。本综述聚焦致癌性MYB与ncRNA之间复杂的相互作用，它们在肿瘤发生中起关键作用，包括增殖、凋亡、血管生成、转移、衰老和耐药。此外，我们还讨论了MYB与ncRNA相互作用的治疗策略，以预防癌症的发生和发展。
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