The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
CAS Key Laboratory of Separatin Science for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy Sciences, Dalian, 116000, China.
Commun Biol. 2021 Dec 7;4(1):1366. doi: 10.1038/s42003-021-02896-3.
Diabetic neuropathy is one of the most prevalent chronic complications of diabetes, and up to half of diabetic patients will develop diabetic neuropathy during their disease course. Notably, emerging evidence suggests that glycemic variability is associated with the pathogenesis of diabetic complications and has emerged as a possible independent risk factor for diabetic neuropathy. In this review, we describe the commonly used metrics for evaluating glycemic variability in clinical practice and summarize the role and related mechanisms of glycemic variability in diabetic neuropathy, including cardiovascular autonomic neuropathy, diabetic peripheral neuropathy and cognitive impairment. In addition, we also address the potential pharmacological and non-pharmacological treatment methods for diabetic neuropathy, aiming to provide ideas for the treatment of diabetic neuropathy.
糖尿病神经病变是糖尿病最常见的慢性并发症之一，多达一半的糖尿病患者在疾病过程中会发展为糖尿病神经病变。值得注意的是，新出现的证据表明，血糖变异性与糖尿病并发症的发病机制有关，并且已经成为糖尿病神经病变的一个可能的独立危险因素。在这篇综述中，我们描述了临床上常用于评估血糖变异性的常用指标，并总结了血糖变异性在糖尿病神经病变中的作用及相关机制，包括心血管自主神经病变、糖尿病周围神经病变和认知障碍。此外，我们还探讨了糖尿病神经病变的潜在药物和非药物治疗方法，旨在为糖尿病神经病变的治疗提供思路。
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