Oxford Katie, Feschuk Aileen, Tibbo Jamie
Faculty of Medicine, Memorial University of Newfoundland, St. John's, CAN.
Cureus. 2021 Nov 3;13(11):e19234. doi: 10.7759/cureus.19234. eCollection 2021 Nov.
Radiotherapy of the head and neck can often lead to complications and side effects, including osteoradionecrosis and soft tissue necrosis. One relatively well-established method of treating osteoradionecrosis includes the PENTOCLO protocol, which consists of Pentoxyllifylline, Tocopherol, and Clodronate. Despite its success in the treatment of osteoradionecrosis, the effectiveness of components of the PENTOCLO protocol in treating soft tissue necrosis of the head and neck is underexplored. This case study reviews the successful treatment of a pyriform sinus ulcer that developed after the use of radiotherapy in treating a T3N2b squamous cell carcinoma. The treatment plan used Pentoxyllifylline and Tocopherol, and omitted Clodronate, and can therefore be referred to as a PENTO protocol.
头颈部放疗常常会导致并发症和副作用，包括放射性骨坏死和软组织坏死。一种相对成熟的治疗放射性骨坏死的方法是PENTOCLO方案，该方案由己酮可可碱、生育酚和氯膦酸盐组成。尽管PENTOCLO方案在治疗放射性骨坏死方面取得了成功，但其组成成分在治疗头颈部软组织坏死方面的有效性尚未得到充分研究。本病例研究回顾了一例在使用放疗治疗T3N2b期鳞状细胞癌后发生的梨状窦溃疡的成功治疗案例。治疗方案使用了己酮可可碱和生育酚，省略了氯膦酸盐，因此可称为PENTO方案。
