Fang Yuan, Yang Yang, Li Na, Zhang Xiao-Li, Huang Han-Fei
Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China.
Department of Otorhinolaryngology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China.
World J Clin Cases. 2021 Nov 16;9(32):9699-9710. doi: 10.12998/wjcc.v9.i32.9699.
Hepatocellular carcinoma (HCC) remains one of the most frequent types of liver cancer and is characterized by a high recurrence rate. Recent studies have proposed that long non-coding RNAs (lncRNAs) are potential biomarkers in several recurrent tumor types. It is now well understood that invasion, migration, and metastasis are important factors for tumor recurrence. Moreover, some of the known risk factors for HCC may affect the expression levels of several types of lncRNAs and thus affect the recurrence of liver cancer through lncRNA regulation. In this paper, we review the biological functions, molecular mechanisms, and roles of lncRNAs in HCC and summarize current knowledge about lncRNAs as potential biomarkers in recurrent HCC.
肝细胞癌（HCC）仍然是最常见的肝癌类型之一，其特点是复发率高。最近的研究表明，长链非编码RNA（lncRNAs）在几种复发性肿瘤类型中是潜在的生物标志物。现在人们已经清楚地认识到，侵袭、迁移和转移是肿瘤复发的重要因素。此外，一些已知的HCC危险因素可能会影响几种lncRNAs的表达水平，从而通过lncRNA调控影响肝癌的复发。在本文中，我们综述了lncRNAs在HCC中的生物学功能、分子机制和作用，并总结了目前关于lncRNAs作为复发性HCC潜在生物标志物的知识。
