与淀粉样蛋白阳性相关的主观认知衰退特征。
Characteristics of subjective cognitive decline associated with amyloid positivity.
作者信息
Janssen Olin, Jansen Willemijn J, Vos Stephanie J B, Boada Merce, Parnetti Lucilla, Gabryelewicz Tomasz, Fladby Tormod, Molinuevo José Luis, Villeneuve Sylvia, Hort Jakub, Epelbaum Stéphane, Lleó Alberto, Engelborghs Sebastiaan, van der Flier Wiesje M, Landau Susan, Popp Julius, Wallin Anders, Scheltens Philip, Rikkert Marcel Olde, Snyder Peter J, Rowe Chris, Chételat Gaël, Ruíz Agustin, Marquié Marta, Chipi Elena, Wolfsgruber Steffen, Heneka Michael, Boecker Henning, Peters Oliver, Jarholm Jonas, Rami Lorena, Tort-Merino Adrià, Binette Alexa Pichet, Poirier Judes, Rosa-Neto Pedro, Cerman Jiri, Dubois Bruno, Teichmann Marc, Alcolea Daniel, Fortea Juan, Sánchez-Saudinós M Belén, Ebenau Jarith, Pocnet Cornelia, Eckerström Marie, Thompson Louisa, Villemagne Victor, Buckley Rachel, Burnham Samantha, Delarue Marion, Freund-Levi Yvonne, Wallin Åsa K, Ramakers Inez, Tsolaki Magda, Soininen Hilkka, Hampel Harald, Spiru Luiza, Tijms Betty, Ossenkoppele Rik, Verhey Frans R J, Jessen Frank, Visser Pieter Jelle
机构信息
Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Fundació ACE, Institut Català de Neurociències Aplicades, Facultat de Medicina, Universitat International de Catalunya-Barcelona, Barcelona, Spain.
出版信息
Alzheimers Dement. 2022 Oct;18(10):1832-1845. doi: 10.1002/alz.12512. Epub 2021 Dec 8.
INTRODUCTION
The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited.
METHODS
In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity.
RESULTS
Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages.
DISCUSSION
Next to age, setting, and APOE ε4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.
引言
与淀粉样蛋白阳性相关的主观认知衰退（SCD）患者特征的证据有限。
方法
在来自20个淀粉样蛋白生物标志物研究队列的1640名SCD患者中，我们调查了SCD特异性特征（知情者确认、特定领域的主诉、担忧、感觉表现变差）、人口统计学、环境、载脂蛋白E基因（APOE）ε4携带者状态以及神经精神症状与淀粉样蛋白阳性之间的关联。
结果
在各队列中，70岁人群的淀粉样蛋白阳性率在10%至76%之间变化。仅年龄较大、临床环境和APOE ε4携带者状态在单变量分析中显示与淀粉样蛋白阳性增加有关。在对这些因素进行调整后，较低的教育水平也与淀粉样蛋白阳性增加有关。仅在研究环境中，知情者确认的主诉、记忆主诉、注意力/集中力主诉以及无抑郁症状与淀粉样蛋白阳性增加有关。感觉表现变差在较年轻年龄与淀粉样蛋白阳性较少相关，而在较年长年龄与淀粉样蛋白阳性较多相关。
讨论
除年龄、环境和APOE ε4携带者状态外，SCD特异性特征可能有助于识别淀粉样蛋白阳性个体。
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