Aβ 与焦虑、抑郁和轻度认知障碍的纵向研究。
A longitudinal investigation of Aβ, anxiety, depression, and mild cognitive impairment.
机构信息
Department of Geriatrics, Paracelsus Medical University, Salzburg, Austria.
Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, Minnesota, USA.
出版信息
Alzheimers Dement. 2022 Oct;18(10):1824-1831. doi: 10.1002/alz.12504. Epub 2021 Dec 8.
INTRODUCTION
We investigated the longitudinal relationship between cortical amyloid deposition, anxiety, and depression and the risk of incident mild cognitive impairment (MCI).
METHODS
We followed 1440 community-dwelling, cognitively unimpaired individuals aged ≥ 50 years for a median of 5.5 years. Clinical anxiety and depression were assessed using Beck Anxiety and Depression Inventories (BAI, BDI-II). Cortical amyloid beta (Aβ) was measured by Pittsburgh compound B positron emission tomography (PiB-PET) and elevated deposition (PiB+) was defined as standardized uptake value ratio ≥ 1.48. We calculated Cox proportional hazards models with age as the time scale, adjusted for sex, education, and medical comorbidity.
RESULTS
Cortical Aβ deposition (PiB+) independent of anxiety (BAI ≥ 10) or depression (BDI-II ≥ 13) increased the risk of MCI. There was a significant additive interaction between PiB+ and anxiety (joint effect hazard ratio 6.77; 95% confidence interval 3.58-12.79; P = .031) that is, being PiB+ and having anxiety further amplified the risk of MCI.
DISCUSSION
Anxiety modified the association between PiB+ and incident MCI.
简介
我们研究了皮质淀粉样蛋白沉积、焦虑和抑郁与轻度认知障碍（MCI）发病风险之间的纵向关系。
方法
我们对 1440 名年龄≥50 岁、认知正常、居住在社区的个体进行了中位时间为 5.5 年的随访。使用贝克焦虑和抑郁量表（BAI、BDI-II）评估临床焦虑和抑郁。采用匹兹堡化合物 B 正电子发射断层扫描（PiB-PET）测量皮质β淀粉样蛋白（Aβ），将标准化摄取值比（SUVR）≥1.48 定义为沉积升高（PiB+）。我们使用 Cox 比例风险模型，以年龄为时间尺度，调整性别、教育程度和合并症。
结果
皮质 Aβ 沉积（PiB+）与焦虑（BAI≥10）或抑郁（BDI-II≥13）无关，增加了 MCI 的发病风险。PiB+与焦虑之间存在显著的相加交互作用（联合效应风险比 6.77；95%置信区间 3.58-12.79；P=0.031），即 PiB+和焦虑进一步放大了 MCI 的发病风险。
讨论
焦虑改变了 PiB+与新发 MCI 之间的关联。
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