Centro de Pesquisa Clínica e Epidemiológica, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brasil.
Divisão de Geriatria, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
Braz J Med Biol Res. 2021 Dec 3;54(12):e11539. doi: 10.1590/1414-431X2021e11539. eCollection 2021.
Sarcopenia and sleep problems share common physiopathology. We aimed to investigate the association of sleep disturbances with sarcopenia and its defining components in Brazilian middle-aged and older adults. In this cross-sectional analysis of the second wave of the ELSA-Brasil study, we included data from 7948 participants aged 50 years and older. Muscle mass was evaluated by bioelectrical impedance analysis and muscle strength by hand-grip strength. Sarcopenia was defined according to the Foundation for the National Institutes of Health criteria. Sleep duration and insomnia complaint were self-reported. Short sleep duration was considered as ≤6 h/night and long sleep duration as >8 h/night. High risk of obstructive sleep apnea (OSA) was assessed using the STOP-Bang questionnaire. Possible confounders included socio-demographic characteristics, lifestyle, clinical comorbidities, and use of sedatives and hypnotics. The frequencies of sarcopenia, low muscle mass, and low muscle strength were 1.6, 21.1, and 4.1%, respectively. After adjustment for possible confounders, high risk of OSA was associated with low muscle mass (OR=2.17, 95%CI: 1.92-2.45). Among obese participants, high risk of OSA was associated with low muscle strength (OR=1.68, 95%CI: 1.07-2.64). However, neither short nor long sleep duration or frequent insomnia complaint were associated with sarcopenia or its defining components. In conclusion, high risk of OSA was associated with low muscle mass in the whole sample and with low muscle strength among obese participants. Future studies are needed to clarify the temporal relationship between both conditions.
肌少症和睡眠问题具有共同的病理生理学。我们旨在研究巴西中年和老年人中睡眠障碍与肌少症及其定义成分的相关性。在 ELSA-Brasil 研究的第二波的横断面分析中，我们纳入了 7948 名年龄在 50 岁及以上的参与者的数据。肌肉质量通过生物电阻抗分析评估，肌肉力量通过手握力评估。根据美国国立卫生研究院标准定义肌少症。睡眠持续时间和失眠抱怨是自我报告的。将短睡眠定义为≤6 小时/夜，长睡眠定义为>8 小时/夜。使用 STOP-Bang 问卷评估阻塞性睡眠呼吸暂停（OSA）的高风险。可能的混杂因素包括社会人口统计学特征、生活方式、临床合并症以及镇静剂和催眠剂的使用。肌少症、低肌肉质量和低肌肉力量的发生率分别为 1.6%、21.1%和 4.1%。在调整可能的混杂因素后，OSA 高风险与低肌肉质量相关（OR=2.17，95%CI：1.92-2.45）。在肥胖参与者中，OSA 高风险与低肌肉力量相关（OR=1.68，95%CI：1.07-2.64）。然而，短睡眠或长睡眠持续时间或频繁失眠抱怨均与肌少症或其定义成分无关。总之，OSA 高风险与全样本中的低肌肉质量以及肥胖参与者中的低肌肉力量相关。需要进一步的研究来阐明这两种情况之间的时间关系。
