Center for clinical and epidemiological research, Hospital Universitario, University of Sao Paulo, Sao Paulo, Brazil.
Center for clinical and epidemiological research, Hospital Universitario, University of Sao Paulo, Sao Paulo, Brazil; Division of Geriatrics, University of Sao Paulo Medical School, Sao Paulo, Brazil.
J Am Med Dir Assoc. 2019 Dec;20(12):1641-1646. doi: 10.1016/j.jamda.2018.09.020. Epub 2018 Nov 5.
To investigate the association of sarcopenia and its defining components with depression in Brazilian middle-aged and older adults.
Cross-sectional study.
This analysis included 5927 participants from the ELSA-Brasil Study second data collection, aged 55 years and older, with complete data for exposure, outcome, and covariates.
Muscle mass was evaluated by bioelectrical impedance analysis and muscle strength by hand-grip strength. Sarcopenia was defined according to the Foundation for the National Institutes of Health (FNIH) criteria. Depression was assessed using the Clinical Interview Scheduled Revised (CIS-R). Information on sociodemographic characteristics, lifestyle, and clinical comorbidities were also obtained.
The frequencies of sarcopenia, presarcopenia, low muscle mass, low muscle strength, and low muscle strength without loss of muscle mass was 1.9%, 18.8%, 20.7%, 4.8%, and 2.9%, respectively. After adjustment for sociodemographic characteristics, clinical conditions, and lifestyle factors, depression was associated with sarcopenia (odds ratio [OR] = 2.23, 95% confidence interval [CI] = 1.11-4.48, P = .024) and low muscle strength (OR = 1.94, 95% CI = 1.20-3.15, P = .007), but it was not associated with presarcopenia, low muscle mass, and low muscle strength without loss of muscle mass.
Depression is associated with sarcopenia defined by the FNIH criteria mainly because of its association with weakness. Future studies are needed to clarify the temporal relationship between both conditions.
调查巴西中老年人群中肌少症及其定义成分与抑郁之间的关系。
横断面研究。
本分析纳入了 ELSA-Brasil 研究第二次数据采集的 5927 名 55 岁及以上的参与者，这些参与者具有完整的暴露、结局和协变量数据。
通过生物电阻抗分析评估肌肉质量，通过手握力评估肌肉力量。根据美国国立卫生研究院基金会（FNIH）标准定义肌少症。使用临床访谈计划修订版（CIS-R）评估抑郁。还收集了社会人口统计学特征、生活方式和临床合并症的信息。
肌少症、肌少前症、肌肉量低、肌肉力量低和肌肉量低而无肌肉力量损失的发生率分别为 1.9%、18.8%、20.7%、4.8%和 2.9%。在调整社会人口统计学特征、临床情况和生活方式因素后，抑郁与肌少症（比值比 [OR] = 2.23，95%置信区间 [CI] = 1.11-4.48，P =.024）和肌肉力量低（OR = 1.94，95% CI = 1.20-3.15，P =.007）相关，但与肌少前症、肌肉量低和肌肉量低而无肌肉力量损失无关。
抑郁与 FNIH 标准定义的肌少症有关，主要是因为它与虚弱有关。需要进一步的研究来阐明这两种情况之间的时间关系。
