Department of Anesthesiology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P.R. China.
Key Laboratory of Cancer Cellular and Molecular Pathology, Cancer Research Institute of Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China.
Mol Med Rep. 2022 Feb;25(2). doi: 10.3892/mmr.2021.12560. Epub 2021 Dec 8.
The κ‑opioid receptor (KOR) is one of the primary receptors of opioids and serves a vital role in the regulation of pain, anesthesia, addiction and other pathological and physiological processes. KOR is associated with several types of cancer and may influence cancer progression. It has been proposed that KOR may represent a new tumor molecular marker and provide a novel basis for molecular targeted therapies for cancer. However, the association between KOR and cancer remains to be explored comprehensively. The present review introduces KOR and its association with different types of cancer. Improved understanding of KOR may facilitate development of novel antitumor therapies.
κ-阿片受体（KOR）是阿片类药物的主要受体之一，在疼痛调节、麻醉、成瘾和其他病理及生理过程中发挥重要作用。KOR 与多种类型的癌症相关，并可能影响癌症的进展。有人提出，KOR 可能代表一种新的肿瘤分子标志物，并为癌症的分子靶向治疗提供新的基础。然而，KOR 与癌症之间的关联仍有待全面探索。本综述介绍了 KOR 及其与不同类型癌症的关系。对 KOR 的深入了解可能有助于开发新型抗肿瘤疗法。
