Center for Inflammation, Translational and Clinical Lung Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Handb Exp Pharmacol. 2022;271:419-433. doi: 10.1007/164_2021_441.
The kappa opioid receptor (KOR) is expressed on a number of hematopoietic cell populations, based on both protein binding analysis and the detection of kappa opioid receptor gene (Oprk1) transcripts. There are prominent Oprk1 splice variants that are expressed in the mouse and human brain cells and leukocytes. The activation of KOR results in reduced antibody production, an inhibition of phagocytic cell activity, an inhibition of T cell development, alterations in the production of various pro-inflammatory cytokines, chemokines, and the receptors for these mediators. Finally, the activation of KOR also leads to the regulation of receptor functional activity of chemokine receptors through the process of heterologous desensitization. The functional activity of KOR is important for the regulation of inflammatory responses and may provide opportunities for the development of therapeutics for the treatment of inflammatory disease states.
κ 阿片受体（KOR）在许多造血细胞群上表达，这基于蛋白结合分析和 κ 阿片受体基因（Oprk1）转录本的检测。在小鼠和人类脑细胞和白细胞中存在显著的 Oprk1 剪接变体。KOR 的激活导致抗体产生减少、吞噬细胞活性抑制、T 细胞发育抑制、各种促炎细胞因子、趋化因子及其介质受体的产生改变。最后，KOR 的激活也通过异源脱敏过程导致趋化因子受体的受体功能活性的调节。KOR 的功能活性对于炎症反应的调节很重要，并且可能为治疗炎症疾病状态的治疗方法的开发提供机会。
