硼氢化铍介导的膦的P(III)导向C-H硼化反应。
BBr -Mediated P(III)-Directed C-H Borylation of Phosphines.
作者信息
Lv Jiahang, Zhang Xue-Jun, Wang Minyan, Zhao Yue, Shi Zhuangzhi
机构信息
State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China.
Department of Orthopedic Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210093, P. R. China.
出版信息
Chemistry. 2022 Feb 16;28(9):e202104100. doi: 10.1002/chem.202104100. Epub 2021 Dec 27.
Transition-metal-catalyzed C-H borylation has been widely used in the preparation of organoboron compounds. Here, we developed a general protocol on metal-free P(III)-directed C-H borylation of phosphines mediated by BBr , resulting in the formation of products bearing both phosphorus and boron. The development of the metal-free strategy to mimic previous metallic processes has shown low cost, superior practicality, and environmental friendliness. Density functional theory (DFT) calculations demonstrate the preferred pathway for this metal-free directed C-H borylation process.
过渡金属催化的C-H硼化反应已广泛应用于有机硼化合物的制备。在此，我们开发了一种通用方法，用于在BBr介导下实现无金属的P(III)导向膦的C-H硼化反应，从而生成同时含有磷和硼的产物。模仿先前金属过程的无金属策略的发展已显示出低成本、卓越的实用性和环境友好性。密度泛函理论(DFT)计算证明了这种无金属导向C-H硼化反应过程的优选途径。
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