Kimber I, Jackson J A, Stonard M D
Toxicol Lett. 1986 Jun;31(3):211-8. doi: 10.1016/0378-4274(86)90128-1.
Natural killer (NK)-cell and T-cell functions have been measured in rats following exposure to either 100 or 1000 ppm lead as lead acetate in drinking water. The capacity of splenocytes isolated from exposed animals to mediate native and interferon (IFN)-activated natural cytotoxicity was measured at three effector:target-cell ratios and found to be normal at all time points examined. Furthermore, splenic T-cell function of treated animals as determined by phytohaemagglutinin (PHA)-induced proliferation was comparable to control values. We conclude that low-level lead exposure is not associated with an impairment of either T-or NK-cell function.
在大鼠饮用含100或1000 ppm醋酸铅的饮用水后，对其天然杀伤（NK）细胞和T细胞功能进行了检测。在三个效应细胞与靶细胞比例下，测量了从暴露动物分离的脾细胞介导天然和干扰素（IFN）激活的自然细胞毒性的能力，发现在所有检测时间点均正常。此外，通过植物血凝素（PHA）诱导的增殖测定的处理动物的脾T细胞功能与对照值相当。我们得出结论，低水平铅暴露与T细胞或NK细胞功能受损无关。
