强效广谱抗生素艾米卡霉素和奇霉素的全合成。
Total Synthesis of the Potent and Broad-Spectrum Antibiotics Amycolamicin and Kibdelomycin.
机构信息
National Institute of Biological Sciences, Beijing, 102206, China.
Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100084, China.
出版信息
J Am Chem Soc. 2021 Dec 22;143(50):21258-21263. doi: 10.1021/jacs.1c11477. Epub 2021 Dec 8.
PMID:34879199
Abstract
The complex and intriguing structures of the antibiotics amycolamicin and kibdelomycin are herein confirmed through total synthesis. Careful titration of the synthetic products reveals that kibdelomycin is the salt form of amycolamicin. This synthesis employs a highly convergent strategy, which provides a modular approach for further SAR studies of this class of antibiotics.
摘要
通过全合成，本文证实了抗生素阿美拉霉素和基二霉素复杂而有趣的结构。对合成产物的仔细滴定表明，基二霉素是阿美拉霉素的盐形式。该合成采用了高度会聚的策略，为进一步研究此类抗生素的 SAR 提供了一种模块化的方法。
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