靶向 CD8 T 细胞的肿瘤免疫治疗——泛酸途径。

CoAching CD8 T cells for tumor immunotherapy-the pantothenate way.

机构信息

Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.

出版信息

Cell Metab. 2021 Dec 7;33(12):2305-2306. doi: 10.1016/j.cmet.2021.11.009.

DOI:10.1016/j.cmet.2021.11.009

Abstract

The metabolic state of T cells strongly influences their effector function and anti-tumor efficacy. St. Paul et al. (2021) report that Tc22, a CD8 T cell subset with potent anti-tumor activity, upregulates the pantothenate/coenzyme A (CoA) pathway and that treatment with CoA or pantothenate is sufficient to enhance tumor immunotherapy.

摘要

T 细胞的代谢状态强烈影响其效应功能和抗肿瘤疗效。St. Paul 等人（2021 年）报告称，Tc22 是一种具有强大抗肿瘤活性的 CD8 T 细胞亚群，其上调泛酸/辅酶 A（CoA）途径，而用 CoA 或泛酸处理足以增强肿瘤免疫治疗。