MRC London Institute of Medical Sciences, London, UK; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
MRC London Institute of Medical Sciences, London, UK; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Cell Metab. 2021 Dec 7;33(12):2307-2309. doi: 10.1016/j.cmet.2021.11.007.
There are dramatic disparities in infection susceptibility within populations. In this issue of Cell Metabolism, Zhao and Karpac uncover a muscle-adipose-gut axis in Drosophila that explains variability in pathogen susceptibility. They show that the degree of intramuscular NF-κB activation accounts for differences in circulating glutamate, which enhances infection resistance at the expense of reproduction.
人群中存在着巨大的感染易感性差异。在本期《细胞代谢》中，Zhao 和 Karpac 揭示了果蝇中的肌肉-脂肪-肠道轴，该轴解释了病原体易感性的可变性。他们表明，肌肉中 NF-κB 激活的程度决定了循环中谷氨酸的差异，这增强了感染抵抗力，但以牺牲繁殖力为代价。
