Program in Cancer Research, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), CIBERONC, Barcelona, Spain; Institut Josep Carreras contra la Leucemia, Barcelona, Spain.
Hematology Department, Parc de Salut Mar-Hospital del Mar, Barcelona, Spain.
Exp Hematol. 2022 Feb;106:3-18. doi: 10.1016/j.exphem.2021.12.191. Epub 2021 Dec 5.
T Cells comprise many subtypes of specified lymphocytes, and their differentiation and function take place in different tissues. This cellular diversity is also observed in the multiple ways T-cell transformation gives rise to a variety of T-cell neoplasms. This review covers the main types of T-cell malignancies and their specific characteristics, emphasizing recent advances at the cellular and molecular levels as well as differences and commonalities among them.
T 细胞包含许多特定淋巴细胞的亚型,其分化和功能发生在不同的组织中。这种细胞多样性也表现在 T 细胞转化产生多种 T 细胞肿瘤的多种方式中。本综述涵盖了 T 细胞恶性肿瘤的主要类型及其特定特征,强调了细胞和分子水平的最新进展以及它们之间的差异和共同点。