Epidemiology and Statistics Research Center/CRESS, INSERM, INRAE, University of Paris, Paris, France.
Department of Neonatal Medicine, Cochin-Port Royal Hospital, FHU PREMA, AP-HP Centre, Paris, France.
Neonatology. 2022;119(1):124-128. doi: 10.1159/000520451. Epub 2021 Dec 8.
Overall and respiratory management of preterm children are constantly evolving, which might have changed both the pathophysiology and neurodevelopmental consequences of bronchopulmonary dysplasia (BPD).
The objective of this study is to determine whether the previously shown association between BPD and risk of developmental delay persists.
The study population was children born before 32 weeks' gestation from the French prospective cohort EPIPAGE-2. The exposure was BPD assessed at 36 weeks' postmenstrual age. The main outcome was risk of developmental delay defined by an Age & Stages Questionnaires (ASQ) score below threshold at 24 months' corrected age.
The analyzed population included 2,706 children. Among those with available ASQ score, 196/1,587 had BPD and 671/1,587 had an ASQ score below threshold. BPD was associated with an ASQ score below threshold (odds ratio 1.52, 95% confidence interval 1.11-2.08; p = 0.008).
BPD was strongly associated with risk of developmental delay.
早产儿的整体和呼吸管理在不断发展，这可能改变了支气管肺发育不良（BPD）的病理生理学和神经发育后果。
本研究旨在确定以前显示的 BPD 与发育迟缓风险之间的关联是否仍然存在。
研究人群为来自法国前瞻性队列 EPIPAGE-2 的胎龄小于 32 周的儿童。暴露是在 36 周的校正胎龄时评估的 BPD。主要结局是发育迟缓的风险，定义为在 24 个月的校正年龄时 ASQ 评分低于阈值。
分析人群包括 2706 名儿童。在有可用 ASQ 评分的儿童中，1587 名中有 196 名患有 BPD，1587 名中有 671 名 ASQ 评分低于阈值。BPD 与 ASQ 评分低于阈值显著相关（比值比 1.52，95%置信区间 1.11-2.08；p=0.008）。
BPD 与发育迟缓的风险密切相关。
