Department of Biomedical Sciences, Faculty of Medicine and Health Sciences Macquarie University, Macquarie, NSW 2109,Australia.
Department of Pharmacology and Therapeutics, The University of Melbourne, VIC 3010,Australia.
Curr Alzheimer Res. 2021;18(10):772-786. doi: 10.2174/1567205018666211208141017.
The Amyloid Precursor Protein (APP) is principally known and studied for its involvement in Alzheimer's disease as the source of the amyloid β peptide; however, its physiological actions within the nervous system are also important as it is involved in a range of neuronal activities, including neurogenesis, synaptic plasticity, neurite outgrowth, and neuroprotection. Of the different neuronal functions that APP can affect, some may be relevant to APP's role in Alzheimer's disease, while others can be primarily related to its physiological roles. This review will focus on APP's neuritogenic actions and surmise the key molecular mechanisms, as well as the structural and signaling requirements, which form the basis for APP's neuritogenic effects. Deciphering the normal function(s) of APP is valuable to properly understanding its role in health as well as Alzheimer's disease.
淀粉样前体蛋白（APP）主要因其作为淀粉样 β 肽的来源而与阿尔茨海默病有关而被人们所熟知和研究；然而，它在神经系统中的生理作用也很重要，因为它参与了一系列神经元活动，包括神经发生、突触可塑性、神经突生长和神经保护。APP 可以影响的不同神经元功能中，有些可能与 APP 在阿尔茨海默病中的作用有关，而有些则主要与其生理作用有关。本综述将重点关注 APP 的促神经突生成作用，并推测其关键分子机制以及形成 APP 促神经突生成作用基础的结构和信号要求。阐明 APP 的正常功能对于正确理解其在健康和阿尔茨海默病中的作用是有价值的。
