Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.
Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, South Korea.
Stroke Vasc Neurol. 2022 Apr;7(2):149-157. doi: 10.1136/svn-2020-000809. Epub 2021 Dec 8.
Takayasu arteritis (TAK) is a disease associated with increased risk of cardiovascular complications. We aimed to evaluate the incidence, prevalence and risk of stroke in patients with TAK.
Data from 1065 patients were obtained from a national database (2010-2018). The annual incidence and prevalence per 100 000 persons were estimated using the registration population in the midst of every year, and the standardised incidence ratio (SIR) of stroke was compared with the general population based on the data from the 2006 national report for cardiovascular and cerebrovascular diseases. Age-adjusted incidence rate ratio (IRR) of stroke based on the time interval after diagnosis was also calculated. A time-dependent Cox regression was conducted to investigate predictive factors of stroke.
The overall incidence rate of TAK ranged between 0.2 and 0.3/100 000 person-years annually; the prevalence of TAK gradually increased, reaching 3.25/100 000 person-years in 2018. Seventy-three (6.9%) patients experienced stroke during follow-up, and the risk of developing stroke was higher than the general population (overall SIR 7.39, 95% CI 5.79 to 9.29; men: SIR 5.70, 95% CI 2.84 to 10.20; women: SIR 7.06, 95% CI 5.41 to 9.05). Most stroke events (90.9%) were cerebral infarction for men, whereas the proportion of cerebral infarction was lower (62.9%) in women. Over half of stroke events occurred within 6 months after diagnosis, and stroke was more common within 6 months of diagnosis compared with after 3 years in women (IRR 13.46, 95% CI 6.86 to 26.40). In Cox regression analysis, age was the sole predictor of stroke (adjusted HR 1.02, 95% CI 1.00 to 1.04, p=0.043).
The annual incidence of TAK was similar to the previous studies from Asia, and the risk of stroke increased in TAK. Different patterns of subtype and incidence of stroke were found according to sex, although age was the only predictor.
Takayasu 动脉炎（TAK）是一种与心血管并发症风险增加相关的疾病。我们旨在评估 TAK 患者中风的发生率、患病率和风险。
从全国数据库（2010-2018 年）中获取了 1065 名患者的数据。使用每年中期的登记人口来估计每 10 万人的年发生率和患病率，并根据 2006 年心血管和脑血管疾病国家报告的数据，比较中风的标准化发病比（SIR）与普通人群。还根据诊断后时间间隔计算了中风的年龄调整发病率比（IRR）。进行时间依赖性 Cox 回归以研究中风的预测因素。
TAK 的总发生率范围为每年 0.2 至 0.3/100000 人；TAK 的患病率逐渐增加，2018 年达到 3.25/100000 人。73 名（6.9%）患者在随访期间发生中风，其发生中风的风险高于普通人群（总 SIR 7.39，95%CI 5.79 至 9.29；男性：SIR 5.70，95%CI 2.84 至 10.20；女性：SIR 7.06，95%CI 5.41 至 9.05）。大多数中风事件（90.9%）为男性的脑梗死，而女性的脑梗死比例较低（62.9%）。超过一半的中风事件发生在诊断后 6 个月内，与女性 3 年后相比，女性在诊断后 6 个月内发生中风的风险更高（IRR 13.46，95%CI 6.86 至 26.40）。在 Cox 回归分析中，年龄是中风的唯一预测因素（调整后的 HR 1.02，95%CI 1.00 至 1.04，p=0.043）。
TAK 的年发生率与亚洲之前的研究相似，TAK 中风的风险增加。尽管年龄是唯一的预测因素，但根据性别，中风的亚类型和发生率存在不同的模式。
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